FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407388699> ?p ?o ?g. }

• W2407388699 endingPage "4495" @default.
• W2407388699 startingPage "4489" @default.
• W2407388699 abstract "Abstract Unfractionated peripheral blood stem cell (PBSC) grafts contain measurable quantities of myeloma cells and are therefore a potential source of relapse posttransplantation. In contrast, fluorescence-activated cell sorting (FACS)-sorted CD34+Thy1+ Lin− peripheral blood cells are substantially enriched for stem cell activity, yet contain virtually no clonal myeloma cells. A study was performed in patients with symptomatic myeloma, who had received 12 months or less of preceding standard chemotherapy, to evaluate the feasibility of large scale purification of primitive hematopoietic stem cells in order to study engraftment kinetics posttransplantation and the degree of tumor cell contamination of this cell population, based on polymerase chain reaction (PCR) analysis for the patient-specific complementarity-determining region III (CDR III). PBSC were mobilized with high dose cyclophosphamide and granulocyte-macrophage colony-stimulating factor (GM-CSF). A combination of elutriation and chemical lysis was used to deplete PBSC collections of monocytes, granulocytes, erythrocytes, and platelets. Subsequently, CD34+ Thy1+ Lin−progenitor cells were purified with high speed cell sorting. Of the 10 evaluable patients, nine met the required minimum criteria of ≥7.2 × 105 cells/kg to support tandem transplants. After high dose melphalan (200 mg/m2) eight engrafted successfully, although granulocyte (absolute neutrophil count [ANC] &gt;0.5 × 109/L, 16 days) and platelet recovery (platelets &gt; 50 × 109/L, 39 days) was substantially delayed when compared with unmanipulated PBSC grafts; one patient required infusion of a reserve graft because of lack of evidence of engraftment by day +28. Three patients proceeded to a second graft with high dose melphalan and total body irradiation; two required infusion of a reserve graft and both died of infectious complications; one showed delayed, but complete, engraftment after this myeloablative regimen. Two of the nine evaluable patients attained a clinical complete remission (CR). The grafts from three patients were tested for tumor contamination and contained no detectable clonal myeloma cells. Larger quantities of purified cells may be required to resolve the problem of delayed engraftment." @default.
• W2407388699 created "2016-06-24" @default.
• W2407388699 creator A5000879635 @default.
• W2407388699 creator A5003008257 @default.
• W2407388699 creator A5003544803 @default.
• W2407388699 creator A5007261675 @default.
• W2407388699 creator A5013355572 @default.
• W2407388699 creator A5018243734 @default.
• W2407388699 creator A5023752321 @default.
• W2407388699 creator A5028046297 @default.
• W2407388699 creator A5031736192 @default.
• W2407388699 creator A5048743123 @default.
• W2407388699 creator A5053047062 @default.
• W2407388699 creator A5061373932 @default.
• W2407388699 creator A5065685597 @default.
• W2407388699 creator A5069439449 @default.
• W2407388699 creator A5069709566 @default.
• W2407388699 creator A5091722266 @default.
• W2407388699 date "1998-06-15" @default.
• W2407388699 modified "2023-10-02" @default.
• W2407388699 title "Collection, Tumor Contamination, and Engraftment Kinetics of Highly Purified Hematopoietic Progenitor Cells to Support High Dose Therapy in Multiple Myeloma" @default.
• W2407388699 cites W145486817 @default.
• W2407388699 cites W1512309466 @default.
• W2407388699 cites W1514172032 @default.
• W2407388699 cites W1526986700 @default.
• W2407388699 cites W1591369027 @default.
• W2407388699 cites W1860497574 @default.
• W2407388699 cites W1898265072 @default.
• W2407388699 cites W1973035870 @default.
• W2407388699 cites W197334239 @default.
• W2407388699 cites W1974084408 @default.
• W2407388699 cites W2000367099 @default.
• W2407388699 cites W2007635748 @default.
• W2407388699 cites W2016176753 @default.
• W2407388699 cites W20342555 @default.
• W2407388699 cites W2107040913 @default.
• W2407388699 cites W2162190929 @default.
• W2407388699 cites W2242711566 @default.
• W2407388699 cites W2271876496 @default.
• W2407388699 cites W2309502478 @default.
• W2407388699 cites W2342210190 @default.
• W2407388699 cites W2343098975 @default.
• W2407388699 cites W2373939791 @default.
• W2407388699 cites W2407783372 @default.
• W2407388699 cites W2418641834 @default.
• W2407388699 cites W2431284569 @default.
• W2407388699 cites W3145716452 @default.
• W2407388699 cites W4248626267 @default.
• W2407388699 cites W4250119920 @default.
• W2407388699 cites W4251664449 @default.
• W2407388699 doi "https://doi.org/10.1182/blood.v91.12.4489" @default.
• W2407388699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9616143" @default.
• W2407388699 hasPublicationYear "1998" @default.
• W2407388699 type Work @default.
• W2407388699 sameAs 2407388699 @default.
• W2407388699 citedByCount "102" @default.
• W2407388699 countsByYear W24073886992012 @default.
• W2407388699 countsByYear W24073886992013 @default.
• W2407388699 countsByYear W24073886992015 @default.
• W2407388699 countsByYear W24073886992016 @default.
• W2407388699 countsByYear W24073886992017 @default.
• W2407388699 countsByYear W24073886992018 @default.
• W2407388699 countsByYear W24073886992020 @default.
• W2407388699 countsByYear W24073886992021 @default.
• W2407388699 countsByYear W24073886992023 @default.
• W2407388699 crossrefType "journal-article" @default.
• W2407388699 hasAuthorship W2407388699A5000879635 @default.
• W2407388699 hasAuthorship W2407388699A5003008257 @default.
• W2407388699 hasAuthorship W2407388699A5003544803 @default.
• W2407388699 hasAuthorship W2407388699A5007261675 @default.
• W2407388699 hasAuthorship W2407388699A5013355572 @default.
• W2407388699 hasAuthorship W2407388699A5018243734 @default.
• W2407388699 hasAuthorship W2407388699A5023752321 @default.
• W2407388699 hasAuthorship W2407388699A5028046297 @default.
• W2407388699 hasAuthorship W2407388699A5031736192 @default.
• W2407388699 hasAuthorship W2407388699A5048743123 @default.
• W2407388699 hasAuthorship W2407388699A5053047062 @default.
• W2407388699 hasAuthorship W2407388699A5061373932 @default.
• W2407388699 hasAuthorship W2407388699A5065685597 @default.
• W2407388699 hasAuthorship W2407388699A5069439449 @default.
• W2407388699 hasAuthorship W2407388699A5069709566 @default.
• W2407388699 hasAuthorship W2407388699A5091722266 @default.
• W2407388699 hasConcept C10205521 @default.
• W2407388699 hasConcept C109159458 @default.
• W2407388699 hasConcept C126322002 @default.
• W2407388699 hasConcept C16685009 @default.
• W2407388699 hasConcept C201750760 @default.
• W2407388699 hasConcept C203014093 @default.
• W2407388699 hasConcept C2776364478 @default.
• W2407388699 hasConcept C2777371436 @default.
• W2407388699 hasConcept C2778630268 @default.
• W2407388699 hasConcept C2778684742 @default.
• W2407388699 hasConcept C2780007613 @default.
• W2407388699 hasConcept C28328180 @default.
• W2407388699 hasConcept C2908647359 @default.
• W2407388699 hasConcept C2911091166 @default.
• W2407388699 hasConcept C502942594 @default.
• W2407388699 hasConcept C553184892 @default.

• next