Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407530596> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2407530596 endingPage "14" @default.
- W2407530596 startingPage "1" @default.
- W2407530596 abstract "The in vitro experimental observations support the theoretical pathogenic scenario depicted in Figure 14. A similar scenario could be portrayed for monocytes. ANCA in the circulation are unable to interact with unprimed neutrophils because the target antigens are within the cytoplasm (Fig. 14A). Synergistic priming of neutrophils, e.g., by an infection, causes small amounts of target antigens to be released at the cell surface (Fig. 14B) where they can interact with ANCA (Fig. 14C). ANCA-activated neutrophils then adhere to endothelial cells via adhesion molecule interactions that may require prior priming of the endothelial cells (Fig. 14C). These activated and adherent neutrophils then injure endothelial cells (and eventually underlying vessel wall structures) by releasing granule enzymes and toxic oxygen metabolites (Fig. 14D). Although many research groups throughout the world have been attempting to create an animal model of ANCA-induced disease based on the theoretical paradigm proposed in Figure 14, as well as on other paradigms, no one has reported complete success. Until this is accomplished, the role of ANCA in the pathogenesis of Wegener’s granulomatosis and other forms of ANCA-associated vasculitides will remain conjectural." @default.
- W2407530596 created "2016-06-24" @default.
- W2407530596 creator A5016307833 @default.
- W2407530596 creator A5041005065 @default.
- W2407530596 creator A5090234704 @default.
- W2407530596 date "1993-02-01" @default.
- W2407530596 modified "2023-10-14" @default.
- W2407530596 title "DO ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES CAUSE WEGENER’S GRANULOMATOSIS AND OTHER FORMS OF NECROTIZING VASCULITIS?" @default.
- W2407530596 cites W1985130760 @default.
- W2407530596 cites W2039582264 @default.
- W2407530596 cites W2052968750 @default.
- W2407530596 cites W2055896786 @default.
- W2407530596 cites W2071298428 @default.
- W2407530596 cites W2086183699 @default.
- W2407530596 cites W2091746620 @default.
- W2407530596 cites W2102431039 @default.
- W2407530596 cites W2105290031 @default.
- W2407530596 cites W2107254198 @default.
- W2407530596 cites W2120922568 @default.
- W2407530596 cites W2132141878 @default.
- W2407530596 cites W2137676749 @default.
- W2407530596 cites W2170737062 @default.
- W2407530596 cites W2182473668 @default.
- W2407530596 cites W2185082079 @default.
- W2407530596 cites W2902766594 @default.
- W2407530596 cites W4255017730 @default.
- W2407530596 doi "https://doi.org/10.1016/s0889-857x(21)00163-0" @default.
- W2407530596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8356246" @default.
- W2407530596 hasPublicationYear "1993" @default.
- W2407530596 type Work @default.
- W2407530596 sameAs 2407530596 @default.
- W2407530596 citedByCount "33" @default.
- W2407530596 countsByYear W24075305962014 @default.
- W2407530596 countsByYear W24075305962016 @default.
- W2407530596 crossrefType "journal-article" @default.
- W2407530596 hasAuthorship W2407530596A5016307833 @default.
- W2407530596 hasAuthorship W2407530596A5041005065 @default.
- W2407530596 hasAuthorship W2407530596A5090234704 @default.
- W2407530596 hasConcept C100701293 @default.
- W2407530596 hasConcept C142724271 @default.
- W2407530596 hasConcept C147483822 @default.
- W2407530596 hasConcept C159654299 @default.
- W2407530596 hasConcept C163764329 @default.
- W2407530596 hasConcept C190062978 @default.
- W2407530596 hasConcept C203014093 @default.
- W2407530596 hasConcept C21194631 @default.
- W2407530596 hasConcept C2776015282 @default.
- W2407530596 hasConcept C2779134260 @default.
- W2407530596 hasConcept C2780942790 @default.
- W2407530596 hasConcept C59822182 @default.
- W2407530596 hasConcept C71924100 @default.
- W2407530596 hasConcept C81444415 @default.
- W2407530596 hasConcept C86803240 @default.
- W2407530596 hasConcept C95444343 @default.
- W2407530596 hasConceptScore W2407530596C100701293 @default.
- W2407530596 hasConceptScore W2407530596C142724271 @default.
- W2407530596 hasConceptScore W2407530596C147483822 @default.
- W2407530596 hasConceptScore W2407530596C159654299 @default.
- W2407530596 hasConceptScore W2407530596C163764329 @default.
- W2407530596 hasConceptScore W2407530596C190062978 @default.
- W2407530596 hasConceptScore W2407530596C203014093 @default.
- W2407530596 hasConceptScore W2407530596C21194631 @default.
- W2407530596 hasConceptScore W2407530596C2776015282 @default.
- W2407530596 hasConceptScore W2407530596C2779134260 @default.
- W2407530596 hasConceptScore W2407530596C2780942790 @default.
- W2407530596 hasConceptScore W2407530596C59822182 @default.
- W2407530596 hasConceptScore W2407530596C71924100 @default.
- W2407530596 hasConceptScore W2407530596C81444415 @default.
- W2407530596 hasConceptScore W2407530596C86803240 @default.
- W2407530596 hasConceptScore W2407530596C95444343 @default.
- W2407530596 hasIssue "1" @default.
- W2407530596 hasLocation W24075305961 @default.
- W2407530596 hasLocation W24075305962 @default.
- W2407530596 hasOpenAccess W2407530596 @default.
- W2407530596 hasPrimaryLocation W24075305961 @default.
- W2407530596 hasRelatedWork W164635967 @default.
- W2407530596 hasRelatedWork W1995376180 @default.
- W2407530596 hasRelatedWork W2013965818 @default.
- W2407530596 hasRelatedWork W2026694394 @default.
- W2407530596 hasRelatedWork W2036054214 @default.
- W2407530596 hasRelatedWork W2036066587 @default.
- W2407530596 hasRelatedWork W2045410073 @default.
- W2407530596 hasRelatedWork W2062030308 @default.
- W2407530596 hasRelatedWork W2135443987 @default.
- W2407530596 hasRelatedWork W3085986429 @default.
- W2407530596 hasVolume "19" @default.
- W2407530596 isParatext "false" @default.
- W2407530596 isRetracted "false" @default.
- W2407530596 magId "2407530596" @default.
- W2407530596 workType "article" @default.