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- W2407536070 abstract "No AccessJournal of Urology1 Mar 1978The Specificity of the Microcytotoxicity Assay for cell-mediated Immunity in Human bladder Cancer M. Vilien and H. Wolf M. VilienM. Vilien More articles by this author and H. WolfH. Wolf More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)57484-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Cytotoxicity of lymphocytes from T1 or T2 bladder cancer patients and patients with other diseases was tested in a 44-hour microcytotoxicity assay against 3 different target cell lines: 1) HU 456, derived from human bladder carcinoma and established in our laboratory, 2) HU 609, a line derived from normal human bladder tissue and established in our laboratory and 3) SAOS-2, a human osteosarcoma cell line from the Memorial Sloan-Kettering Cancer Institute. Lymphocyte concentrations ranging from 7.8 time 104 to 2.5 times 106 lymphocytes per ml. were tested against each cell line. Lymphocytes from both groups of patients demonstrated a cytotoxicity against all 3 target cell lines, proportional to the lymphocyte concentration used. There was no difference in reactivity to HU 609 or to SAOS-2 between bladder cancer and control patients but the lymphocytes of bladder cancer patients showed a statistically greater cytotoxicity for HU 456, demonstrating a tumor type-specific cellular immune reaction superimposed on a background of non-specific cytotoxicity. © 1978 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLajzerowicz M, Thomson D and Reid E (2018) A Study of the Immune Response to the Organ-Specific Neoantigen of Human Bladder CancerJournal of Urology, VOL. 128, NO. 5, (1122-1129), Online publication date: 1-Nov-1982. Volume 119Issue 3March 1978Page: 338-342 Advertisement Copyright & Permissions© 1978 by The American Urological Association Education and Research, Inc.MetricsAuthor Information M. Vilien More articles by this author H. Wolf More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W2407536070 title "The Specificity of the Microcytotoxicity Assay for cell-mediated Immunity in Human bladder Cancer" @default.
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