FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407610466> ?p ?o ?g. }

• W2407610466 endingPage "14" @default.
• W2407610466 startingPage "3" @default.
• W2407610466 abstract "The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest that the YAP paralogue TAZ (gene symbol WWTR1) functions as YAP but, in skeletal muscle, TAZ has been reported to promote myogenic differentiation, whereas YAP inhibits it. Here, we investigated whether TAZ is also a rhabdomyosarcoma oncogene or whether TAZ acts as a YAP antagonist. Immunostaining of rhabdomyosarcoma tissue microarrays revealed that TAZ is significantly associated with poor survival in ERMS. In 12% of fusion gene-negative rhabdomyosarcomas, the TAZ locus is gained, which is correlated with increased expression. Constitutively active TAZ S89A significantly increased proliferation of C2C12 myoblasts and, importantly, colony formation on soft agar, suggesting transformation. However, TAZ then switches to enhance myogenic differentiation in C2C12 myoblasts, unlike YAP. Conversely, lentiviral shRNA-mediated TAZ knockdown in human ERMS cells reduced proliferation and anchorage-independent growth. While TAZ S89A or YAP1 S127A similarly activated the 8XGTIIC-Luc Hippo reporter, only YAP1 S127A activated the Brachyury (T-box) reporter. Consistent with its oncogene function, TAZ S89A induced expression of the ERMS cancer stem cell gene Myf5 and the serine biosynthesis pathway (Phgdh, Psat1, Psph) in C2C12 myoblasts. Thus, TAZ is associated with poor survival in ERMS and could act as an oncogene in rhabdomyosarcoma. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland." @default.
• W2407610466 created "2016-06-24" @default.
• W2407610466 creator A5008962448 @default.
• W2407610466 creator A5025388990 @default.
• W2407610466 creator A5036576443 @default.
• W2407610466 creator A5036806948 @default.
• W2407610466 creator A5038856063 @default.
• W2407610466 creator A5051590155 @default.
• W2407610466 creator A5057899222 @default.
• W2407610466 creator A5074131244 @default.
• W2407610466 creator A5074587312 @default.
• W2407610466 date "2016-08-22" @default.
• W2407610466 modified "2023-10-17" @default.
• W2407610466 title "The Hippo effector<scp>TAZ</scp>(<i><scp>WWTR1</scp></i>) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma" @default.
• W2407610466 cites W1107917109 @default.
• W2407610466 cites W1504229479 @default.
• W2407610466 cites W1532539575 @default.
• W2407610466 cites W1567765448 @default.
• W2407610466 cites W1825669598 @default.
• W2407610466 cites W1872124954 @default.
• W2407610466 cites W1963272969 @default.
• W2407610466 cites W1970351212 @default.
• W2407610466 cites W1981697868 @default.
• W2407610466 cites W1986676916 @default.
• W2407610466 cites W1991623155 @default.
• W2407610466 cites W2000121424 @default.
• W2407610466 cites W2001714642 @default.
• W2407610466 cites W2004480757 @default.
• W2407610466 cites W2011121500 @default.
• W2407610466 cites W2016758942 @default.
• W2407610466 cites W2018705590 @default.
• W2407610466 cites W2020511240 @default.
• W2407610466 cites W2022899908 @default.
• W2407610466 cites W2024424959 @default.
• W2407610466 cites W2030433725 @default.
• W2407610466 cites W2031486950 @default.
• W2407610466 cites W2040430549 @default.
• W2407610466 cites W2043398720 @default.
• W2407610466 cites W2053250920 @default.
• W2407610466 cites W2064610366 @default.
• W2407610466 cites W2064644124 @default.
• W2407610466 cites W2073157874 @default.
• W2407610466 cites W2076819367 @default.
• W2407610466 cites W2085039090 @default.
• W2407610466 cites W2091694499 @default.
• W2407610466 cites W2095426342 @default.
• W2407610466 cites W2096622475 @default.
• W2407610466 cites W2114031931 @default.
• W2407610466 cites W2114427673 @default.
• W2407610466 cites W2114843025 @default.
• W2407610466 cites W2116201681 @default.
• W2407610466 cites W2119501563 @default.
• W2407610466 cites W2126524529 @default.
• W2407610466 cites W2127736279 @default.
• W2407610466 cites W2129436528 @default.
• W2407610466 cites W2129472307 @default.
• W2407610466 cites W2139160260 @default.
• W2407610466 cites W2141595533 @default.
• W2407610466 cites W2144283689 @default.
• W2407610466 cites W2146337514 @default.
• W2407610466 cites W2146934598 @default.
• W2407610466 cites W2149441684 @default.
• W2407610466 cites W2157912474 @default.
• W2407610466 cites W2159670921 @default.
• W2407610466 cites W2161616384 @default.
• W2407610466 cites W2167978765 @default.
• W2407610466 cites W2168280550 @default.
• W2407610466 cites W2168636113 @default.
• W2407610466 cites W2171879013 @default.
• W2407610466 cites W2228198088 @default.
• W2407610466 cites W2621932433 @default.
• W2407610466 doi "https://doi.org/10.1002/path.4745" @default.
• W2407610466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995731" @default.
• W2407610466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27184927" @default.
• W2407610466 hasPublicationYear "2016" @default.
• W2407610466 type Work @default.
• W2407610466 sameAs 2407610466 @default.
• W2407610466 citedByCount "35" @default.
• W2407610466 countsByYear W24076104662016 @default.
• W2407610466 countsByYear W24076104662017 @default.
• W2407610466 countsByYear W24076104662018 @default.
• W2407610466 countsByYear W24076104662019 @default.
• W2407610466 countsByYear W24076104662020 @default.
• W2407610466 countsByYear W24076104662021 @default.
• W2407610466 countsByYear W24076104662022 @default.
• W2407610466 countsByYear W24076104662023 @default.
• W2407610466 crossrefType "journal-article" @default.
• W2407610466 hasAuthorship W2407610466A5008962448 @default.
• W2407610466 hasAuthorship W2407610466A5025388990 @default.
• W2407610466 hasAuthorship W2407610466A5036576443 @default.
• W2407610466 hasAuthorship W2407610466A5036806948 @default.
• W2407610466 hasAuthorship W2407610466A5038856063 @default.
• W2407610466 hasAuthorship W2407610466A5051590155 @default.
• W2407610466 hasAuthorship W2407610466A5057899222 @default.
• W2407610466 hasAuthorship W2407610466A5074131244 @default.
• W2407610466 hasAuthorship W2407610466A5074587312 @default.
• W2407610466 hasBestOaLocation W24076104661 @default.
• W2407610466 hasConcept C104317684 @default.

• next