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- W2407611030 endingPage "50" @default.
- W2407611030 startingPage "50" @default.
- W2407611030 abstract "Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate Wnt receptors. Frizzled7 is highly conserved through evolution, from Hydra through to humans, and is expressed in diverse organisms, tissues and human disease contexts. Frizzled receptors can homo- or hetero-polymerise and associate with several co-receptors to transmit Wnt signalling. Notably, Frizzled7 can transmit signalling via multiple Wnt transduction pathways and bind to several different Wnt ligands, Frizzled receptors and co-receptors. These promiscuous binding and functional properties are thought to underlie the pivotal role Frizzled7 plays in embryonic developmental and stem cell function. Recent studies have identified that Frizzled7 is upregulated in diverse human cancers, and promotes proliferation, progression and invasion, and orchestrates cellular transitions that underscore cancer metastasis. Importantly, Frizzled7 is able to regulate Wnt signalling activity even in cancer cells which have mutations to down-stream signal transducers. In this review we discuss the various aspects of Frizzled7 signalling and function, and the implications these have for therapeutic targeting of Frizzled7 in cancer." @default.
- W2407611030 created "2016-06-24" @default.
- W2407611030 creator A5055930277 @default.
- W2407611030 creator A5057990773 @default.
- W2407611030 creator A5067834126 @default.
- W2407611030 date "2016-05-17" @default.
- W2407611030 modified "2023-10-15" @default.
- W2407611030 title "Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer" @default.
- W2407611030 cites W1117369035 @default.
- W2407611030 cites W1480706413 @default.
- W2407611030 cites W1488246691 @default.
- W2407611030 cites W1498931318 @default.
- W2407611030 cites W1528865568 @default.
- W2407611030 cites W1536067283 @default.
- W2407611030 cites W1573866353 @default.
- W2407611030 cites W1631692643 @default.
- W2407611030 cites W1638846196 @default.
- W2407611030 cites W1655178001 @default.
- W2407611030 cites W1664587663 @default.
- W2407611030 cites W1702807246 @default.
- W2407611030 cites W1784854092 @default.
- W2407611030 cites W1902879109 @default.
- W2407611030 cites W1928785194 @default.
- W2407611030 cites W1939628694 @default.
- W2407611030 cites W1956332901 @default.
- W2407611030 cites W1958727809 @default.
- W2407611030 cites W1963934527 @default.
- W2407611030 cites W1964081206 @default.
- W2407611030 cites W1965619419 @default.
- W2407611030 cites W1967073403 @default.
- W2407611030 cites W1969202196 @default.
- W2407611030 cites W1971079902 @default.
- W2407611030 cites W1971085650 @default.
- W2407611030 cites W1971906974 @default.
- W2407611030 cites W1973267581 @default.
- W2407611030 cites W1974094726 @default.
- W2407611030 cites W1974319293 @default.
- W2407611030 cites W1974942829 @default.
- W2407611030 cites W1975711182 @default.
- W2407611030 cites W1975993620 @default.
- W2407611030 cites W1977590575 @default.
- W2407611030 cites W1979618971 @default.
- W2407611030 cites W1980141592 @default.
- W2407611030 cites W1980432649 @default.
- W2407611030 cites W1981440982 @default.
- W2407611030 cites W1983253019 @default.
- W2407611030 cites W1983376202 @default.
- W2407611030 cites W1985146880 @default.
- W2407611030 cites W1985193507 @default.
- W2407611030 cites W1985831802 @default.
- W2407611030 cites W1987966039 @default.
- W2407611030 cites W1987993854 @default.
- W2407611030 cites W1989662404 @default.
- W2407611030 cites W1990053396 @default.
- W2407611030 cites W1990606472 @default.
- W2407611030 cites W1991738093 @default.
- W2407611030 cites W1993487095 @default.
- W2407611030 cites W1993677820 @default.
- W2407611030 cites W1994603523 @default.
- W2407611030 cites W1994979890 @default.
- W2407611030 cites W1996583924 @default.
- W2407611030 cites W1996900960 @default.
- W2407611030 cites W1997208865 @default.
- W2407611030 cites W1997452920 @default.
- W2407611030 cites W1999408122 @default.
- W2407611030 cites W1999966222 @default.
- W2407611030 cites W2004499736 @default.
- W2407611030 cites W2006419043 @default.
- W2407611030 cites W2007490905 @default.
- W2407611030 cites W2009379859 @default.
- W2407611030 cites W2009684443 @default.
- W2407611030 cites W2010522614 @default.
- W2407611030 cites W2011623297 @default.
- W2407611030 cites W2013204587 @default.
- W2407611030 cites W2013754009 @default.
- W2407611030 cites W2013891209 @default.
- W2407611030 cites W2015456200 @default.
- W2407611030 cites W2015567417 @default.
- W2407611030 cites W2016654611 @default.
- W2407611030 cites W2017531120 @default.
- W2407611030 cites W2017632960 @default.
- W2407611030 cites W2017668082 @default.
- W2407611030 cites W2017807559 @default.
- W2407611030 cites W2018448892 @default.
- W2407611030 cites W2019535129 @default.
- W2407611030 cites W2020459782 @default.
- W2407611030 cites W2021370278 @default.
- W2407611030 cites W2021723599 @default.
- W2407611030 cites W2023186669 @default.
- W2407611030 cites W2024432674 @default.
- W2407611030 cites W2026089403 @default.
- W2407611030 cites W2028456873 @default.
- W2407611030 cites W2029609524 @default.
- W2407611030 cites W2029764098 @default.
- W2407611030 cites W2032598213 @default.
- W2407611030 cites W2035523809 @default.
- W2407611030 cites W2036811006 @default.
- W2407611030 cites W2039313867 @default.