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- W2407623613 abstract "It is difficult to predict the clinical activity of antibiotics solely on the basis of in vitro data. Experimental models measuring the relationship between serum concentration and in vivo activity are essential for comparing the activity of different compounds currently available. The critical serum concentration can be used to compare the intrinsic activity of antibiotics on a given bacterial strain. When compared with the minimal inhibiting concentration measured in vitro, activity loss can be determined for each antibiotic placed in contact with bacteria in an infected tissue. The relevance of this therapeutic tool in comparison with other methods is discussed." @default.
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- W2407623613 date "1995-04-29" @default.
- W2407623613 modified "2023-09-23" @default.
- W2407623613 title "[Critical serum concentration of antibiotics. A therapeutic tool and means of comparative evaluation]." @default.
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