FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407650432> ?p ?o ?g. }

• W2407650432 abstract "Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SAHA is a histone deacetylase inhibitor that regulates gene expression by increasing chromatin histone acetylation. In this study, we investigated the role of SAHA in TLR4/MYD88 signaling in a rat seizure model. Sprague–Dawley rats with kainic acid (KA)-induced seizures were treated with SAHA. The expression of TLR4, MYD88, NF-κB P65 and IL-1β in hippocampus was detected at hour 2 and 6 and day 1, 2, and 3 post seizure. SAHA pretreatment increased seizure latency and decreased seizure scores. The expression levels of TLR4, MYD88, NF-κB and IL-1β increased significantly in both activated microglia and apoptotic neurons after KA treatment. The effects were attenuated by SAHA. Chromatin immunoprecipitation assays indicated that the H3 histone acetylation levels significantly decreased while H3K9 levels significantly increased in the KA treatment group. The H3 and H3K9 acetylation levels returned to control levels after SAHA (50 mg/kg) pretreatment. There was a positive correlation between the expression of TLR4 and the acetylation levels of H3K9. Histone deacetylase inhibitor SAHA can suppress seizure-induced TLR4/MYD88 signaling and inhibit TLR4 gene expression through histone acetylation regulation. This suggests that SAHA may protect against seizure-induced brain damage." @default.
• W2407650432 created "2016-06-24" @default.
• W2407650432 creator A5017811443 @default.
• W2407650432 creator A5061018303 @default.
• W2407650432 date "2016-05-18" @default.
• W2407650432 modified "2023-10-11" @default.
• W2407650432 title "Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation" @default.
• W2407650432 cites W1600829492 @default.
• W2407650432 cites W1603732963 @default.
• W2407650432 cites W1655903008 @default.
• W2407650432 cites W17169411 @default.
• W2407650432 cites W1767777404 @default.
• W2407650432 cites W1853997446 @default.
• W2407650432 cites W1968241110 @default.
• W2407650432 cites W1969023959 @default.
• W2407650432 cites W1969120088 @default.
• W2407650432 cites W1970581535 @default.
• W2407650432 cites W1980541855 @default.
• W2407650432 cites W1984616248 @default.
• W2407650432 cites W1984949963 @default.
• W2407650432 cites W1995132116 @default.
• W2407650432 cites W1995744610 @default.
• W2407650432 cites W2002698073 @default.
• W2407650432 cites W2003753749 @default.
• W2407650432 cites W2005312649 @default.
• W2407650432 cites W2009649161 @default.
• W2407650432 cites W2011718960 @default.
• W2407650432 cites W2024803597 @default.
• W2407650432 cites W2028811090 @default.
• W2407650432 cites W2030056523 @default.
• W2407650432 cites W2031855726 @default.
• W2407650432 cites W2033804029 @default.
• W2407650432 cites W2057528850 @default.
• W2407650432 cites W2058365710 @default.
• W2407650432 cites W2058464768 @default.
• W2407650432 cites W2058693141 @default.
• W2407650432 cites W2059223526 @default.
• W2407650432 cites W2075845422 @default.
• W2407650432 cites W2081412831 @default.
• W2407650432 cites W2081678164 @default.
• W2407650432 cites W2081689918 @default.
• W2407650432 cites W2085251042 @default.
• W2407650432 cites W2092384816 @default.
• W2407650432 cites W2092700031 @default.
• W2407650432 cites W2093318093 @default.
• W2407650432 cites W2096240982 @default.
• W2407650432 cites W2097293665 @default.
• W2407650432 cites W2098597348 @default.
• W2407650432 cites W2103946141 @default.
• W2407650432 cites W2105180380 @default.
• W2407650432 cites W2109759840 @default.
• W2407650432 cites W2110877402 @default.
• W2407650432 cites W2115185894 @default.
• W2407650432 cites W2116116157 @default.
• W2407650432 cites W2121264285 @default.
• W2407650432 cites W2123355863 @default.
• W2407650432 cites W2124667416 @default.
• W2407650432 cites W2127669990 @default.
• W2407650432 cites W2144679012 @default.
• W2407650432 cites W2154663804 @default.
• W2407650432 cites W2167141364 @default.
• W2407650432 cites W2219379015 @default.
• W2407650432 cites W2409139576 @default.
• W2407650432 cites W253358839 @default.
• W2407650432 cites W324759871 @default.
• W2407650432 cites W4239006274 @default.
• W2407650432 cites W847268110 @default.
• W2407650432 doi "https://doi.org/10.1186/s12868-016-0264-9" @default.
• W2407650432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4872358" @default.
• W2407650432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27193049" @default.
• W2407650432 hasPublicationYear "2016" @default.
• W2407650432 type Work @default.
• W2407650432 sameAs 2407650432 @default.
• W2407650432 citedByCount "31" @default.
• W2407650432 countsByYear W24076504322016 @default.
• W2407650432 countsByYear W24076504322017 @default.
• W2407650432 countsByYear W24076504322018 @default.
• W2407650432 countsByYear W24076504322019 @default.
• W2407650432 countsByYear W24076504322020 @default.
• W2407650432 countsByYear W24076504322021 @default.
• W2407650432 countsByYear W24076504322022 @default.
• W2407650432 countsByYear W24076504322023 @default.
• W2407650432 crossrefType "journal-article" @default.
• W2407650432 hasAuthorship W2407650432A5017811443 @default.
• W2407650432 hasAuthorship W2407650432A5061018303 @default.
• W2407650432 hasBestOaLocation W24076504321 @default.
• W2407650432 hasConcept C101762097 @default.
• W2407650432 hasConcept C104317684 @default.
• W2407650432 hasConcept C119157956 @default.
• W2407650432 hasConcept C126322002 @default.
• W2407650432 hasConcept C134320426 @default.
• W2407650432 hasConcept C150194340 @default.
• W2407650432 hasConcept C153911025 @default.
• W2407650432 hasConcept C185592680 @default.
• W2407650432 hasConcept C2776070231 @default.
• W2407650432 hasConcept C2776202225 @default.
• W2407650432 hasConcept C2776745794 @default.
• W2407650432 hasConcept C2776914184 @default.
• W2407650432 hasConcept C2778305200 @default.
• W2407650432 hasConcept C2779830541 @default.

• next