Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407702982> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2407702982 abstract "Non-small cell lung cancer (NSCLC) is the major subtype of lung cancer, accounting for about 85% of all lung patients. Recently, molecularly targeted inhibitors of receptor tyrosine kinase (RTK) such as epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) signalling pathways have been highlighted as promising anti-tumor drugs because of the prevalence of genetic alterations within EGFR and FGFR signalling pathways in NSCLC patients. However, their functional effects have been reported as varying over a wide range depending on the patient-specific mutational conditions. To understand the underlying mechanism of the heterogeneous responses to EGFR and FGFR inhibitors and to find the optimal strategy for combination therapy, we have developed an integrative Boolean network model of EGFR, FGFR and DNA damage signalling pathways by integrating previous experimental evidences from the literature. Systematic perturbation analysis revealed that the multiple feedback regulations embedded in the signalling pathways play important roles in determining the responses to EGFR and FGFR inhibitors. We further analyzed the mechanism for the heterogeneous responses of cells to the EGFR and FGFR inhibitors under various mutational conditions and identified key genetic alterations that can lead to undesirable responses. Finally, extensive combinatorial perturbation analysis and subsequent comparison of the attractor profiles in the presence and absence of targeted inhibitors identified novel candidate drug targets for combinatorial therapy. Our analysis provides a new insight into the underlying mechanism of the heterogeneous cellular responses to EGFR and FGFR inhibitors and the optimal combinatorial treatment strategies. Acknowledgements: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea Government, the Ministry of Science, ICT & Future Planning (2014R1A2A1A10052404, 2013M3A9A7046303, and 2010-0017662) and by a grant of the Korean Health Technology RD Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B2-27." @default.
- W2407702982 created "2016-06-24" @default.
- W2407702982 creator A5034286632 @default.
- W2407702982 creator A5070990802 @default.
- W2407702982 date "2015-11-15" @default.
- W2407702982 modified "2023-09-27" @default.
- W2407702982 title "Abstract B2-27: Systems biological identification of optimal drug targets for combination therapy of non-small cell lung cancer" @default.
- W2407702982 doi "https://doi.org/10.1158/1538-7445.compsysbio-b2-27" @default.
- W2407702982 hasPublicationYear "2015" @default.
- W2407702982 type Work @default.
- W2407702982 sameAs 2407702982 @default.
- W2407702982 citedByCount "0" @default.
- W2407702982 crossrefType "proceedings-article" @default.
- W2407702982 hasAuthorship W2407702982A5034286632 @default.
- W2407702982 hasAuthorship W2407702982A5070990802 @default.
- W2407702982 hasConcept C101544691 @default.
- W2407702982 hasConcept C121608353 @default.
- W2407702982 hasConcept C143998085 @default.
- W2407702982 hasConcept C170493617 @default.
- W2407702982 hasConcept C2776256026 @default.
- W2407702982 hasConcept C2777506169 @default.
- W2407702982 hasConcept C2779438470 @default.
- W2407702982 hasConcept C2781230642 @default.
- W2407702982 hasConcept C42362537 @default.
- W2407702982 hasConcept C502942594 @default.
- W2407702982 hasConcept C54355233 @default.
- W2407702982 hasConcept C62478195 @default.
- W2407702982 hasConcept C70721500 @default.
- W2407702982 hasConcept C71924100 @default.
- W2407702982 hasConcept C74373430 @default.
- W2407702982 hasConcept C82867764 @default.
- W2407702982 hasConcept C86803240 @default.
- W2407702982 hasConceptScore W2407702982C101544691 @default.
- W2407702982 hasConceptScore W2407702982C121608353 @default.
- W2407702982 hasConceptScore W2407702982C143998085 @default.
- W2407702982 hasConceptScore W2407702982C170493617 @default.
- W2407702982 hasConceptScore W2407702982C2776256026 @default.
- W2407702982 hasConceptScore W2407702982C2777506169 @default.
- W2407702982 hasConceptScore W2407702982C2779438470 @default.
- W2407702982 hasConceptScore W2407702982C2781230642 @default.
- W2407702982 hasConceptScore W2407702982C42362537 @default.
- W2407702982 hasConceptScore W2407702982C502942594 @default.
- W2407702982 hasConceptScore W2407702982C54355233 @default.
- W2407702982 hasConceptScore W2407702982C62478195 @default.
- W2407702982 hasConceptScore W2407702982C70721500 @default.
- W2407702982 hasConceptScore W2407702982C71924100 @default.
- W2407702982 hasConceptScore W2407702982C74373430 @default.
- W2407702982 hasConceptScore W2407702982C82867764 @default.
- W2407702982 hasConceptScore W2407702982C86803240 @default.
- W2407702982 hasLocation W24077029821 @default.
- W2407702982 hasOpenAccess W2407702982 @default.
- W2407702982 hasPrimaryLocation W24077029821 @default.
- W2407702982 hasRelatedWork W1489240871 @default.
- W2407702982 hasRelatedWork W1507295026 @default.
- W2407702982 hasRelatedWork W1576833680 @default.
- W2407702982 hasRelatedWork W1969903643 @default.
- W2407702982 hasRelatedWork W1995065292 @default.
- W2407702982 hasRelatedWork W2015495715 @default.
- W2407702982 hasRelatedWork W2072346087 @default.
- W2407702982 hasRelatedWork W2139046059 @default.
- W2407702982 hasRelatedWork W2260880079 @default.
- W2407702982 hasRelatedWork W2352491315 @default.
- W2407702982 hasRelatedWork W2600903921 @default.
- W2407702982 hasRelatedWork W2767986744 @default.
- W2407702982 hasRelatedWork W2909259623 @default.
- W2407702982 hasRelatedWork W3012479410 @default.
- W2407702982 hasRelatedWork W3014703486 @default.
- W2407702982 hasRelatedWork W3035686614 @default.
- W2407702982 hasRelatedWork W3161101550 @default.
- W2407702982 hasRelatedWork W3200212065 @default.
- W2407702982 hasRelatedWork W3209457472 @default.
- W2407702982 hasRelatedWork W96999353 @default.
- W2407702982 isParatext "false" @default.
- W2407702982 isRetracted "false" @default.
- W2407702982 magId "2407702982" @default.
- W2407702982 workType "article" @default.