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- W2407771166 abstract "Objective To investigate the in situ expression of regulatory T cells (Tress) in thymus and its significance for myasthenia gravis (MG). Methods Thirty nine MG patients who had not accepted immunosuppressive therapy before thymectomy were recruited as study group and 19 patients undergoing eardiosurgery as control. There was no significant statistical difference in age and gender between the two groups (P> 0.05) . The location and proportion of Tress in thymus were analyzed using indirect immunofluorescence double labeling immunohistochemistry and image analysis software. Results (1) Tress were all located in medulla zone of thymus in control and MG groups. (2) Cells of germinal center had a high expression of CD25 and a low expression of CD4. It indicates that a majority of germinal center cells were B cells. (3) There were fewer Tress around germinal center. (4) There was no statistical significant difference in absolute number of Tregs between the two groups (P > 0.05). But the proportion of Tress was higher in control group (P < 0.05). Conclusion The proportion of thymus Tress decreases in MG so as to weaken the function of immuno-regulation and suppression. This is probably a precipitating factor of MG.Key words: Myasthenia gratis; Thymus; Regulatory T cells" @default.
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- W2407771166 date "2009-11-24" @default.
- W2407771166 modified "2023-09-24" @default.
- W2407771166 title "Expression of regulatory T cells in thymus of myasthenia gravis patients" @default.
- W2407771166 doi "https://doi.org/10.3760/cma.j.issn.0376-2491.2009.43.003" @default.
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