Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407867250> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2407867250 endingPage "E109" @default.
- W2407867250 startingPage "E105" @default.
- W2407867250 abstract "To determine if insulin has the ability to regulate components of the renin-angiotensin system, renin and angiotensinogen mRNA and plasma concentrations were determined in 4-wk streptozotocin (STZ)-diabetic rats. In another group of STZ-diabetic rats, replacement insulin therapy was given over the 4-wk period, and the above parameters were examined. In STZ-diabetic rats, there was a significant regression of white adipose tissue that was accompanied by an increase in the yield of RNA obtained. Changes in white adipose tissue were reversed by insulin replacement therapy in STZ-diabetic rats. There were no changes in brown adipose tissue weight or RNA yield in STZ-diabetic rats. Plasma renin activity (PRA) was significantly decreased in STZ-diabetic rats; however, plasma angiotensinogen concentration was not significantly affected by diabetes. PRA was restored to control levels in STZ-diabetic rats with insulin replacement. Kidney renin mRNA as well as liver, epididymal, and interscapular fat angiotensinogen mRNA were significantly decreased in STZ-diabetic rats. Renin and angiotensinogen mRNA were not significantly different from control in all tissues examined in STZ-diabetic rats with insulin replacement therapy. Results from this study suggest a downregulation of the renin-angiotensin system in 4-wk STZ-diabetic rats at the level of mRNA expression that is restored by replacement therapy with insulin; therefore, insulin may directly or indirectly regulate the renin-angiotensin system." @default.
- W2407867250 created "2016-06-24" @default.
- W2407867250 creator A5056417722 @default.
- W2407867250 date "1992-01-01" @default.
- W2407867250 modified "2023-09-23" @default.
- W2407867250 title "Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats" @default.
- W2407867250 cites W1493674896 @default.
- W2407867250 cites W1964496243 @default.
- W2407867250 cites W1975622210 @default.
- W2407867250 cites W1983068955 @default.
- W2407867250 cites W1984075500 @default.
- W2407867250 cites W2004043215 @default.
- W2407867250 cites W2013572211 @default.
- W2407867250 cites W2016543968 @default.
- W2407867250 cites W2023172518 @default.
- W2407867250 cites W2059557437 @default.
- W2407867250 cites W2060333964 @default.
- W2407867250 cites W2070610716 @default.
- W2407867250 cites W2102586984 @default.
- W2407867250 cites W2113883680 @default.
- W2407867250 cites W2126030103 @default.
- W2407867250 cites W2144648694 @default.
- W2407867250 cites W2160740604 @default.
- W2407867250 cites W2410712514 @default.
- W2407867250 cites W2414374609 @default.
- W2407867250 doi "https://doi.org/10.1152/ajpendo.1992.262.1.e105" @default.
- W2407867250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1733240" @default.
- W2407867250 hasPublicationYear "1992" @default.
- W2407867250 type Work @default.
- W2407867250 sameAs 2407867250 @default.
- W2407867250 citedByCount "21" @default.
- W2407867250 countsByYear W24078672502013 @default.
- W2407867250 countsByYear W24078672502015 @default.
- W2407867250 countsByYear W24078672502016 @default.
- W2407867250 countsByYear W24078672502019 @default.
- W2407867250 crossrefType "journal-article" @default.
- W2407867250 hasAuthorship W2407867250A5056417722 @default.
- W2407867250 hasConcept C104317684 @default.
- W2407867250 hasConcept C126322002 @default.
- W2407867250 hasConcept C127561419 @default.
- W2407867250 hasConcept C134018914 @default.
- W2407867250 hasConcept C138976137 @default.
- W2407867250 hasConcept C151955695 @default.
- W2407867250 hasConcept C171089720 @default.
- W2407867250 hasConcept C185592680 @default.
- W2407867250 hasConcept C198710026 @default.
- W2407867250 hasConcept C2779280383 @default.
- W2407867250 hasConcept C2779306644 @default.
- W2407867250 hasConcept C2780091579 @default.
- W2407867250 hasConcept C55493867 @default.
- W2407867250 hasConcept C555293320 @default.
- W2407867250 hasConcept C71924100 @default.
- W2407867250 hasConcept C84393581 @default.
- W2407867250 hasConceptScore W2407867250C104317684 @default.
- W2407867250 hasConceptScore W2407867250C126322002 @default.
- W2407867250 hasConceptScore W2407867250C127561419 @default.
- W2407867250 hasConceptScore W2407867250C134018914 @default.
- W2407867250 hasConceptScore W2407867250C138976137 @default.
- W2407867250 hasConceptScore W2407867250C151955695 @default.
- W2407867250 hasConceptScore W2407867250C171089720 @default.
- W2407867250 hasConceptScore W2407867250C185592680 @default.
- W2407867250 hasConceptScore W2407867250C198710026 @default.
- W2407867250 hasConceptScore W2407867250C2779280383 @default.
- W2407867250 hasConceptScore W2407867250C2779306644 @default.
- W2407867250 hasConceptScore W2407867250C2780091579 @default.
- W2407867250 hasConceptScore W2407867250C55493867 @default.
- W2407867250 hasConceptScore W2407867250C555293320 @default.
- W2407867250 hasConceptScore W2407867250C71924100 @default.
- W2407867250 hasConceptScore W2407867250C84393581 @default.
- W2407867250 hasIssue "1" @default.
- W2407867250 hasLocation W24078672501 @default.
- W2407867250 hasLocation W24078672502 @default.
- W2407867250 hasOpenAccess W2407867250 @default.
- W2407867250 hasPrimaryLocation W24078672501 @default.
- W2407867250 hasRelatedWork W1957106181 @default.
- W2407867250 hasRelatedWork W2036460863 @default.
- W2407867250 hasRelatedWork W2044897248 @default.
- W2407867250 hasRelatedWork W2056633665 @default.
- W2407867250 hasRelatedWork W2081564223 @default.
- W2407867250 hasRelatedWork W2131147582 @default.
- W2407867250 hasRelatedWork W2159949415 @default.
- W2407867250 hasRelatedWork W2407867250 @default.
- W2407867250 hasRelatedWork W2434287781 @default.
- W2407867250 hasRelatedWork W4253482381 @default.
- W2407867250 hasVolume "262" @default.
- W2407867250 isParatext "false" @default.
- W2407867250 isRetracted "false" @default.
- W2407867250 magId "2407867250" @default.
- W2407867250 workType "article" @default.