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- W2407894005 abstract "Skin ulcers are defined as tissue loss interesting the deeper layers of the dermis and hypodermis, with low tendency to spontaneous healing. They cause disability related to pain, risk of infection and amputation, chronic management, requiring working absence with notably economic burden. The major cause is often related to underlying vascular disease, infections, tumors, autoimmunity, trauma, even if literature occasionally reported several cases of drug inducing skin ulceration. Most of drugs involved are chemotherapy agents and more recently molecular target therapies. Evidences supporting these drugs as the major cause of skin ulcers include delay of onset after therapy initiation, improvement after withdrawal of the drug, recurrence after its reintroduction and, sometimes, simultaneous occurrence of other skin lesions that have previously been reported to be associated with these agents. Attention should be reserved to patients undergoing antineoplastic agents, especially if previously affected by predisposing comorbidities, considering such side effect as possible differential diagnosis for skin ulceration in neoplastic patients." @default.
- W2407894005 created "2016-06-24" @default.
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- W2407894005 date "2014-01-01" @default.
- W2407894005 modified "2023-09-26" @default.
- W2407894005 title "Drug cutaneous side effect: focus on skin ulceration." @default.
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- W2407894005 doi "https://doi.org/10.7417/ct.2014.1750" @default.
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