FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407894805> ?p ?o ?g. }

• W2407894805 endingPage "668" @default.
• W2407894805 startingPage "661" @default.
• W2407894805 abstract "Fragment D (Mr 100 000) prepared from a terminal plasmin digest of fibrinogen was isolated and used to study its effect on fibrin formation. Increasing amounts of fragment D added to a solution of fibrinogen and thrombin decrease the rigidity of the resultant gel (10% of control at 2 mol of fragment D/mol of fibrinogen). Half-maximal inhibition is achieved at 1 mol of fragment D/mol of fibrinogen for non-cross-linked clots and at 1/2 mol of fragment D/mol of fibrinogen for cross-linked clots. ‘Clottability’ decreases concomitantly with the rigidity. Only small amounts of fragment D (less than 10% for non-cross-linked gels) are incorporated into the gel. Light-scattering shows an increase in the final fibre thickness at fragment D concentrations up to 2 mol of fragment D/mol of fibrinogen, from 60 molecules/cross-section for the control to 120 molecules/cross-section. Higher fragment D concentrations lead to a decrease in the final fibre thickness. The limit fibre thickness is 8 nm, with a length of 80 nm, which is equivalent to a fibrin trimer. On the basis of results of synthetic-substrate and fibrinopeptide-release assays, it is clear that thrombin inactivation is not responsible for this effect. These data suggest that fragment D may inhibit fibrin formation by blocking the bimolecular polymerization of activated fibrin monomer molecules to form protofibrils, although additional effects on subsequent assembly steps may also be involved." @default.
• W2407894805 created "2016-06-24" @default.
• W2407894805 creator A5005639290 @default.
• W2407894805 creator A5014143393 @default.
• W2407894805 creator A5038627792 @default.
• W2407894805 creator A5051552056 @default.
• W2407894805 date "1981-09-01" @default.
• W2407894805 modified "2023-09-25" @default.
• W2407894805 title "Characterization of the inhibition of fibrin assembly by fibrinogen fragment D" @default.
• W2407894805 cites W1483507325 @default.
• W2407894805 cites W1507424043 @default.
• W2407894805 cites W1517933273 @default.
• W2407894805 cites W1530018620 @default.
• W2407894805 cites W1554425830 @default.
• W2407894805 cites W1604635179 @default.
• W2407894805 cites W1606042850 @default.
• W2407894805 cites W1814751417 @default.
• W2407894805 cites W194382395 @default.
• W2407894805 cites W1979427668 @default.
• W2407894805 cites W1982207241 @default.
• W2407894805 cites W1990922681 @default.
• W2407894805 cites W1994542189 @default.
• W2407894805 cites W1999504108 @default.
• W2407894805 cites W2016357659 @default.
• W2407894805 cites W2019272875 @default.
• W2407894805 cites W2027141031 @default.
• W2407894805 cites W2033474964 @default.
• W2407894805 cites W2034622062 @default.
• W2407894805 cites W2046220306 @default.
• W2407894805 cites W2058613232 @default.
• W2407894805 cites W2064755136 @default.
• W2407894805 cites W2065041660 @default.
• W2407894805 cites W2066835643 @default.
• W2407894805 cites W2078531679 @default.
• W2407894805 cites W2083596829 @default.
• W2407894805 cites W2088826683 @default.
• W2407894805 cites W2093447025 @default.
• W2407894805 cites W2107430366 @default.
• W2407894805 cites W2146172466 @default.
• W2407894805 cites W2160124075 @default.
• W2407894805 cites W2160805842 @default.
• W2407894805 cites W2164707254 @default.
• W2407894805 cites W2413002376 @default.
• W2407894805 cites W2428859037 @default.
• W2407894805 cites W2460119913 @default.
• W2407894805 cites W2471661770 @default.
• W2407894805 cites W2411089697 @default.
• W2407894805 doi "https://doi.org/10.1042/bj1970661" @default.
• W2407894805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1163178" @default.
• W2407894805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7325975" @default.
• W2407894805 hasPublicationYear "1981" @default.
• W2407894805 type Work @default.
• W2407894805 sameAs 2407894805 @default.
• W2407894805 citedByCount "25" @default.
• W2407894805 countsByYear W24078948052017 @default.
• W2407894805 crossrefType "journal-article" @default.
• W2407894805 hasAuthorship W2407894805A5005639290 @default.
• W2407894805 hasAuthorship W2407894805A5014143393 @default.
• W2407894805 hasAuthorship W2407894805A5038627792 @default.
• W2407894805 hasAuthorship W2407894805A5051552056 @default.
• W2407894805 hasBestOaLocation W24078948052 @default.
• W2407894805 hasConcept C121332964 @default.
• W2407894805 hasConcept C12554922 @default.
• W2407894805 hasConcept C148898269 @default.
• W2407894805 hasConcept C159985019 @default.
• W2407894805 hasConcept C166940927 @default.
• W2407894805 hasConcept C175156509 @default.
• W2407894805 hasConcept C178790620 @default.
• W2407894805 hasConcept C181199279 @default.
• W2407894805 hasConcept C185592680 @default.
• W2407894805 hasConcept C192562407 @default.
• W2407894805 hasConcept C199360897 @default.
• W2407894805 hasConcept C203014093 @default.
• W2407894805 hasConcept C2776235265 @default.
• W2407894805 hasConcept C2776403692 @default.
• W2407894805 hasConcept C2777292125 @default.
• W2407894805 hasConcept C2779036427 @default.
• W2407894805 hasConcept C2779546866 @default.
• W2407894805 hasConcept C2781071845 @default.
• W2407894805 hasConcept C32909587 @default.
• W2407894805 hasConcept C41008148 @default.
• W2407894805 hasConcept C43369102 @default.
• W2407894805 hasConcept C43617362 @default.
• W2407894805 hasConcept C44228677 @default.
• W2407894805 hasConcept C521977710 @default.
• W2407894805 hasConcept C54173615 @default.
• W2407894805 hasConcept C55493867 @default.
• W2407894805 hasConcept C62520636 @default.
• W2407894805 hasConcept C71240020 @default.
• W2407894805 hasConcept C86803240 @default.
• W2407894805 hasConcept C89560881 @default.
• W2407894805 hasConceptScore W2407894805C121332964 @default.
• W2407894805 hasConceptScore W2407894805C12554922 @default.
• W2407894805 hasConceptScore W2407894805C148898269 @default.
• W2407894805 hasConceptScore W2407894805C159985019 @default.
• W2407894805 hasConceptScore W2407894805C166940927 @default.
• W2407894805 hasConceptScore W2407894805C175156509 @default.
• W2407894805 hasConceptScore W2407894805C178790620 @default.

• next