Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407921962> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2407921962 endingPage "602" @default.
- W2407921962 startingPage "600" @default.
- W2407921962 abstract "OBJECTIVE To investigate the inhibitory effects of anisodamine (654-2) and pentoxifylline (PTX) on the expression of lipopolysaccharide (LPS)-induced intercellular adhesion molecule-1 (ICAM-1) in rat cardiac muscle in vivo. METHODS The animals were randomly divided into five groups (each n=6): (1) normal control group, (2) model group, (3) 654-2 treated group, (4) PTX treated group and (5) 654-2+PTX treated group. The endotoxemia model was reproduced by intravenous injection LPS 5 mg/kg. The expression of ICAM-1 protein in rat cardiac muscle was assayed by Western blotting at 0, 2, 4, 6, 8, 10 hours after intravenous LPS injection. Then the expression of ICAM-1 protein in different groups was assayed at different time points. RESULTS The changes in expression of ICAM-1 in rat cardiac muscle after LPS injection were in a time-dependent pattern, gradually elevating to approach the peak at 6 th, then it lowered, but it still appeared at 10 hours (P<0.05). Western blotting also showed that ICAM-1 protein with decreased with pre-treatment of 654-2 or PTX respectively (both P<0.01). It was reduced to a much lower level when the animals were pretreated with a combination of 654-2 and PTX, compared with the group of 654-2 alone or PTX alone (both P<0.05). CONCLUSION The combination of 654-2 and PTX may play a protective role in rat against injury to cardiac muscle induced by LPS in vivo via inhibiting the production of ICAM-1 protein." @default.
- W2407921962 created "2016-06-24" @default.
- W2407921962 creator A5008350810 @default.
- W2407921962 creator A5033498255 @default.
- W2407921962 creator A5080737652 @default.
- W2407921962 creator A5081844561 @default.
- W2407921962 creator A5082821854 @default.
- W2407921962 date "2007-10-01" @default.
- W2407921962 modified "2023-09-25" @default.
- W2407921962 title "[Inhibitory effects of anisodamine and pentoxifylline on the expression of lipopolysaccharide -induced intercellular adhesion molecule-1 in rat cardiac muscle]." @default.
- W2407921962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17945081" @default.
- W2407921962 hasPublicationYear "2007" @default.
- W2407921962 type Work @default.
- W2407921962 sameAs 2407921962 @default.
- W2407921962 citedByCount "0" @default.
- W2407921962 crossrefType "journal-article" @default.
- W2407921962 hasAuthorship W2407921962A5008350810 @default.
- W2407921962 hasAuthorship W2407921962A5033498255 @default.
- W2407921962 hasAuthorship W2407921962A5080737652 @default.
- W2407921962 hasAuthorship W2407921962A5081844561 @default.
- W2407921962 hasAuthorship W2407921962A5082821854 @default.
- W2407921962 hasConcept C104317684 @default.
- W2407921962 hasConcept C126322002 @default.
- W2407921962 hasConcept C134018914 @default.
- W2407921962 hasConcept C150903083 @default.
- W2407921962 hasConcept C207001950 @default.
- W2407921962 hasConcept C2776914184 @default.
- W2407921962 hasConcept C2778754761 @default.
- W2407921962 hasConcept C2778996579 @default.
- W2407921962 hasConcept C2779686630 @default.
- W2407921962 hasConcept C2780404050 @default.
- W2407921962 hasConcept C2909375385 @default.
- W2407921962 hasConcept C55493867 @default.
- W2407921962 hasConcept C71924100 @default.
- W2407921962 hasConcept C79879829 @default.
- W2407921962 hasConcept C85265743 @default.
- W2407921962 hasConcept C86803240 @default.
- W2407921962 hasConcept C98274493 @default.
- W2407921962 hasConceptScore W2407921962C104317684 @default.
- W2407921962 hasConceptScore W2407921962C126322002 @default.
- W2407921962 hasConceptScore W2407921962C134018914 @default.
- W2407921962 hasConceptScore W2407921962C150903083 @default.
- W2407921962 hasConceptScore W2407921962C207001950 @default.
- W2407921962 hasConceptScore W2407921962C2776914184 @default.
- W2407921962 hasConceptScore W2407921962C2778754761 @default.
- W2407921962 hasConceptScore W2407921962C2778996579 @default.
- W2407921962 hasConceptScore W2407921962C2779686630 @default.
- W2407921962 hasConceptScore W2407921962C2780404050 @default.
- W2407921962 hasConceptScore W2407921962C2909375385 @default.
- W2407921962 hasConceptScore W2407921962C55493867 @default.
- W2407921962 hasConceptScore W2407921962C71924100 @default.
- W2407921962 hasConceptScore W2407921962C79879829 @default.
- W2407921962 hasConceptScore W2407921962C85265743 @default.
- W2407921962 hasConceptScore W2407921962C86803240 @default.
- W2407921962 hasConceptScore W2407921962C98274493 @default.
- W2407921962 hasIssue "10" @default.
- W2407921962 hasLocation W24079219621 @default.
- W2407921962 hasLocation W24079219622 @default.
- W2407921962 hasOpenAccess W2407921962 @default.
- W2407921962 hasPrimaryLocation W24079219621 @default.
- W2407921962 hasRelatedWork W1969924107 @default.
- W2407921962 hasRelatedWork W1975423229 @default.
- W2407921962 hasRelatedWork W2002814423 @default.
- W2407921962 hasRelatedWork W2350600304 @default.
- W2407921962 hasRelatedWork W2357287331 @default.
- W2407921962 hasRelatedWork W2361962370 @default.
- W2407921962 hasRelatedWork W2364897363 @default.
- W2407921962 hasRelatedWork W2372010108 @default.
- W2407921962 hasRelatedWork W2385114537 @default.
- W2407921962 hasRelatedWork W2388295822 @default.
- W2407921962 hasRelatedWork W2390218410 @default.
- W2407921962 hasRelatedWork W2393998692 @default.
- W2407921962 hasRelatedWork W2415665423 @default.
- W2407921962 hasRelatedWork W2549555877 @default.
- W2407921962 hasRelatedWork W2741367807 @default.
- W2407921962 hasRelatedWork W3028612224 @default.
- W2407921962 hasRelatedWork W3028628816 @default.
- W2407921962 hasRelatedWork W3029759273 @default.
- W2407921962 hasRelatedWork W3144842511 @default.
- W2407921962 hasRelatedWork W3152339081 @default.
- W2407921962 hasVolume "19" @default.
- W2407921962 isParatext "false" @default.
- W2407921962 isRetracted "false" @default.
- W2407921962 magId "2407921962" @default.
- W2407921962 workType "article" @default.