FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407993699> ?p ?o ?g. }

• W2407993699 endingPage "745" @default.
• W2407993699 startingPage "745" @default.
• W2407993699 abstract "Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis (Mtb), presenting 9.5 million new cases and 1.5 million deaths in 2014. The aim of this study was to evaluate a nanostructured lipid system (NLS) composed of 10% phase oil (cholesterol), 10% surfactant (soy phosphatidylcholine, sodium oleate), and Eumulgin® HRE 40 ([castor oil polyoxyl-40-hydrogenated] in a proportion of 3:6:8), and an 80% aqueous phase (phosphate buffer pH = 7.4) as a tactic to enhance the in vitro anti-Mtb activity of the copper(II) complexes [CuCl2(INH)2]·H2O (1), [Cu(NCS)2(INH)2]·5H2O (2) and [Cu(NCO)2(INH)2]·4H2O (3). The Cu(II) complex-loaded NLS displayed sizes ranging from 169.5 ± 0.7095 to 211.1 ± 0.8963 nm, polydispersity index (PDI) varying from 0.135 ± 0.0130 to 0.236 ± 0.00100, and zeta potential ranging from −0.00690 ± 0.0896 to −8.43 ± 1.63 mV. Rheological analysis showed that the formulations behave as non-Newtonian fluids of the pseudoplastic and viscoelastic type. Antimycobacterial activities of the free complexes and NLS-loaded complexes against Mtb H37Rv ATCC 27294 were evaluated by the REMA methodology, and the selectivity index (SI) was calculated using the cytotoxicity index (IC50) against Vero (ATCC® CCL-81), J774A.1 (ATCC® TIB-67), and MRC-5 (ATCC® CCL-171) cell lines. The data suggest that the incorporation of the complexes into NLS improved the inhibitory action against Mtb by 52-, 27-, and 4.7-fold and the SI values by 173-, 43-, and 7-fold for the compounds 1, 2 and 3, respectively. The incorporation of the complexes 1, 2 and 3 into the NLS also resulted in a significant decrease of toxicity towards an alternative model (Artemia salina L.). These findings suggest that the NLS may be considered as a platform for incorporation of metallic complexes aimed at the treatment of TB." @default.
• W2407993699 created "2016-06-24" @default.
• W2407993699 creator A5006642862 @default.
• W2407993699 creator A5015469685 @default.
• W2407993699 creator A5028456611 @default.
• W2407993699 creator A5034525232 @default.
• W2407993699 creator A5036140897 @default.
• W2407993699 creator A5040100425 @default.
• W2407993699 creator A5046914694 @default.
• W2407993699 creator A5056606353 @default.
• W2407993699 creator A5076973012 @default.
• W2407993699 date "2016-05-17" @default.
• W2407993699 modified "2023-10-01" @default.
• W2407993699 title "In Vitro Activity of Copper(II) Complexes, Loaded or Unloaded into a Nanostructured Lipid System, against Mycobacterium tuberculosis" @default.
• W2407993699 cites W1561098119 @default.
• W2407993699 cites W1575252897 @default.
• W2407993699 cites W1967888121 @default.
• W2407993699 cites W1974164137 @default.
• W2407993699 cites W1975453911 @default.
• W2407993699 cites W1982441697 @default.
• W2407993699 cites W1996488396 @default.
• W2407993699 cites W1999374190 @default.
• W2407993699 cites W2012204980 @default.
• W2407993699 cites W2016812928 @default.
• W2407993699 cites W2018478936 @default.
• W2407993699 cites W2020972687 @default.
• W2407993699 cites W2021476498 @default.
• W2407993699 cites W2023337431 @default.
• W2407993699 cites W2031673647 @default.
• W2407993699 cites W2042474898 @default.
• W2407993699 cites W2048378109 @default.
• W2407993699 cites W2051172714 @default.
• W2407993699 cites W2053245283 @default.
• W2407993699 cites W2059257002 @default.
• W2407993699 cites W206248798 @default.
• W2407993699 cites W2070173820 @default.
• W2407993699 cites W2079014892 @default.
• W2407993699 cites W2108059588 @default.
• W2407993699 cites W2112891180 @default.
• W2407993699 cites W2116128143 @default.
• W2407993699 cites W2151470000 @default.
• W2407993699 cites W2173602532 @default.
• W2407993699 cites W2200413417 @default.
• W2407993699 cites W2200895684 @default.
• W2407993699 cites W2259068583 @default.
• W2407993699 cites W2275754131 @default.
• W2407993699 cites W2431247573 @default.
• W2407993699 doi "https://doi.org/10.3390/ijms17050745" @default.
• W2407993699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4881567" @default.
• W2407993699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27196901" @default.
• W2407993699 hasPublicationYear "2016" @default.
• W2407993699 type Work @default.
• W2407993699 sameAs 2407993699 @default.
• W2407993699 citedByCount "24" @default.
• W2407993699 countsByYear W24079936992017 @default.
• W2407993699 countsByYear W24079936992018 @default.
• W2407993699 countsByYear W24079936992020 @default.
• W2407993699 countsByYear W24079936992021 @default.
• W2407993699 countsByYear W24079936992022 @default.
• W2407993699 countsByYear W24079936992023 @default.
• W2407993699 crossrefType "journal-article" @default.
• W2407993699 hasAuthorship W2407993699A5006642862 @default.
• W2407993699 hasAuthorship W2407993699A5015469685 @default.
• W2407993699 hasAuthorship W2407993699A5028456611 @default.
• W2407993699 hasAuthorship W2407993699A5034525232 @default.
• W2407993699 hasAuthorship W2407993699A5036140897 @default.
• W2407993699 hasAuthorship W2407993699A5040100425 @default.
• W2407993699 hasAuthorship W2407993699A5046914694 @default.
• W2407993699 hasAuthorship W2407993699A5056606353 @default.
• W2407993699 hasAuthorship W2407993699A5076973012 @default.
• W2407993699 hasBestOaLocation W24079936991 @default.
• W2407993699 hasConcept C109316439 @default.
• W2407993699 hasConcept C11432220 @default.
• W2407993699 hasConcept C13965031 @default.
• W2407993699 hasConcept C142724271 @default.
• W2407993699 hasConcept C155672457 @default.
• W2407993699 hasConcept C171250308 @default.
• W2407993699 hasConcept C176947019 @default.
• W2407993699 hasConcept C178790620 @default.
• W2407993699 hasConcept C185592680 @default.
• W2407993699 hasConcept C192562407 @default.
• W2407993699 hasConcept C202751555 @default.
• W2407993699 hasConcept C2776330855 @default.
• W2407993699 hasConcept C2777975735 @default.
• W2407993699 hasConcept C2778918659 @default.
• W2407993699 hasConcept C2779685592 @default.
• W2407993699 hasConcept C2781069245 @default.
• W2407993699 hasConcept C41625074 @default.
• W2407993699 hasConcept C544778455 @default.
• W2407993699 hasConcept C55493867 @default.
• W2407993699 hasConcept C71924100 @default.
• W2407993699 hasConcept C86181022 @default.
• W2407993699 hasConceptScore W2407993699C109316439 @default.
• W2407993699 hasConceptScore W2407993699C11432220 @default.
• W2407993699 hasConceptScore W2407993699C13965031 @default.
• W2407993699 hasConceptScore W2407993699C142724271 @default.
• W2407993699 hasConceptScore W2407993699C155672457 @default.
• W2407993699 hasConceptScore W2407993699C171250308 @default.

• next