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• W2407996846 endingPage "1670" @default.
• W2407996846 startingPage "1661" @default.
• W2407996846 abstract "Benign prostatic hyperplasia (BPH) is a disease affecting most of the elderly male. α1-blockers and 5-alpha reductase inhibitors are currently used to target lower urinary tract symptoms (LUTS). Moreover phytotherapeutic agents, including Serenoa Repens (SeR), have shown to have a role in ameliorating BPH/LUTS alone or in combination of other elements like Selenium (Se) and Lycopene (Ly). Areas covered: A literature review was performed using data from articles assessing the role of of SeR+Se+Ly in the management of LUTS secondary to BPH. Diverging evidence on SeR's efficacy is available. On one hand several studies have shown SeR efficacy in treating BPH/LUTS. SeR is effective in reducing prostate size, urinary frequency, dysuria, nocturia and in improving maximum urine flow-rate. On the other hand two long-term trials reported that SeR did not improve prostate size or urinary flow. SeR+Se+Ly in combination with tamsulosin is more effective than single therapies in improving IPSS and increasing maximal urinary flow-rate in patients affected by LUTS/BPH. Expert opinion: Despite great amount of preclinical and clinical studies, the use of SeR in BPH/LUTS is not sustained by clear evidence for a therapeutic efficacy but current data hint higher efficacy of of SeR+Se+Ly compared to SeR alone." @default.
• W2407996846 created "2016-06-24" @default.
• W2407996846 creator A5013771798 @default.
• W2407996846 creator A5029050000 @default.
• W2407996846 creator A5031550729 @default.
• W2407996846 creator A5054485016 @default.
• W2407996846 creator A5056920953 @default.
• W2407996846 creator A5061623935 @default.
• W2407996846 creator A5072937184 @default.
• W2407996846 creator A5076870899 @default.
• W2407996846 creator A5078919686 @default.
• W2407996846 date "2016-06-01" @default.
• W2407996846 modified "2023-09-23" @default.
• W2407996846 title "Serenoa repens, selenium and lycopene to manage lower urinary tract symptoms suggestive for benign prostatic hyperplasia" @default.
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