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- W2408029645 abstract "Circulating tumor cell clusters (CTCCs) are significantly more likely to form metastases than single tumor cells. We demonstrate the potential of backscatter-based flow cytometry (BSFC) to detect unique light scattering signatures of CTCCs in the blood of mice orthotopically implanted with breast cancer cells and treated with an anti-ADAM8 or a control antibody. Based on scattering detected at 405, 488, and 633 nm from blood samples flowing through microfluidic devices, we identified 14 CTCCs with large scattering peak widths and intensities, whose presence correlated strongly with metastasis. These initial studies demonstrate the potential to detect CTCCs via label-free BSFC." @default.
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- W2408029645 date "2016-02-25" @default.
- W2408029645 modified "2023-09-27" @default.
- W2408029645 title "Endogenous light scattering as an optical signature of circulating tumor cell clusters" @default.
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- W2408029645 doi "https://doi.org/10.1364/boe.7.001042" @default.
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