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• W2408045167 abstract "Obesity is an increasing health problem not only in the industrialized western countries but, also in the developing countries like India. The adipose tissue specific obese (Ob) gene and its peptide product leptin were discovered in 1994. Since then, a plethora of studies on its important function in regulating body weight have been undertaken and has opened a whole new field of research. Although the role of leptin on obesity has been reviewed extensively, our knowledge of its physiological role(s) is not fully known and is an ever-growing subject. Leptin binding to specific receptors in the hypothalamus results in altered expression of orexigenic and anorexigenic neuropeptides that regulate neuroendocrine function and energy homeostasis, and recent experimental evidence suggests that leptin plays an important role in the pathogenesis of obesity and eating disorders. This review will attempt to give a summary of the main physiological actions of leptin in the body and to explore the possibility of the leptin feedback system being used as a basis for the development of new drugs to combat obesity." @default.
• W2408045167 created "2016-06-24" @default.
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• W2408045167 date "2012-01-01" @default.
• W2408045167 modified "2023-09-27" @default.
• W2408045167 title "The Physiological Role of Leptin: A Review" @default.
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