Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408103693> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2408103693 abstract "Abstract There is evidence from clinical studies and animal experiments that aspirin has a greater antithrombotic activity in males compared to females. We investigated platelet function in vitro and in vivo in rabbits before and after the administration of a dose of aspirin (5 mg/kg) which inhibited collagen stimulated thromboxane B2 generation. Infusion of collagen into untreated animals resulted in a 38 +/- 4% (m +/- SE, n = 13) decrease in platelet count (assessed by whole blood radioactivity) in the male animals, and a 27 +/- 3% (m +/- SE, n = 13) in the female animals. Pretreatment with aspirin resulted in a significant inhibitory effect in the male but not the female animals (p less than 0.05). The male animals had significantly greater thromboxane B2 generation in vivo than did the female animals following an equal dose of collagen (males, 2.64 +/- 0.7 ng/ml thromboxane B2, n = 14; females, 1.67 +/- 0.4 ng/ml thromboxane B2, n = 15, p less than 0.05). In contrast no sex related difference in the inhibitory effect of aspirin on maximal collagen induced aggregation was found when platelets were studied in vitro. The greater reactivity of male patients in vivo may be accounted for by the observed increase in thromboxane B2 generation. This might also explain the greater thrombotic tendency of males, and the observed difference in the antithrombotic effect of aspirin in males and females." @default.
- W2408103693 created "2016-06-24" @default.
- W2408103693 creator A5000914852 @default.
- W2408103693 creator A5016063336 @default.
- W2408103693 creator A5059310871 @default.
- W2408103693 creator A5075115394 @default.
- W2408103693 date "1982-03-01" @default.
- W2408103693 modified "2023-09-29" @default.
- W2408103693 title "Sex related differences in platelet function: the effect of aspirin" @default.
- W2408103693 cites W1516218620 @default.
- W2408103693 cites W1980817754 @default.
- W2408103693 cites W2037182962 @default.
- W2408103693 cites W2140482107 @default.
- W2408103693 cites W2162637702 @default.
- W2408103693 cites W2246347275 @default.
- W2408103693 cites W2323719464 @default.
- W2408103693 cites W2336435715 @default.
- W2408103693 cites W2410855914 @default.
- W2408103693 doi "https://doi.org/10.1182/blood.v59.3.625.625" @default.
- W2408103693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7059670" @default.
- W2408103693 hasPublicationYear "1982" @default.
- W2408103693 type Work @default.
- W2408103693 sameAs 2408103693 @default.
- W2408103693 citedByCount "24" @default.
- W2408103693 countsByYear W24081036932012 @default.
- W2408103693 countsByYear W24081036932014 @default.
- W2408103693 countsByYear W24081036932015 @default.
- W2408103693 countsByYear W24081036932017 @default.
- W2408103693 crossrefType "journal-article" @default.
- W2408103693 hasAuthorship W2408103693A5000914852 @default.
- W2408103693 hasAuthorship W2408103693A5016063336 @default.
- W2408103693 hasAuthorship W2408103693A5059310871 @default.
- W2408103693 hasAuthorship W2408103693A5075115394 @default.
- W2408103693 hasBestOaLocation W24081036931 @default.
- W2408103693 hasConcept C126322002 @default.
- W2408103693 hasConcept C134018914 @default.
- W2408103693 hasConcept C150903083 @default.
- W2408103693 hasConcept C207001950 @default.
- W2408103693 hasConcept C2776785769 @default.
- W2408103693 hasConcept C2777015399 @default.
- W2408103693 hasConcept C2777628954 @default.
- W2408103693 hasConcept C2781024287 @default.
- W2408103693 hasConcept C2781080829 @default.
- W2408103693 hasConcept C71924100 @default.
- W2408103693 hasConcept C86803240 @default.
- W2408103693 hasConcept C89560881 @default.
- W2408103693 hasConceptScore W2408103693C126322002 @default.
- W2408103693 hasConceptScore W2408103693C134018914 @default.
- W2408103693 hasConceptScore W2408103693C150903083 @default.
- W2408103693 hasConceptScore W2408103693C207001950 @default.
- W2408103693 hasConceptScore W2408103693C2776785769 @default.
- W2408103693 hasConceptScore W2408103693C2777015399 @default.
- W2408103693 hasConceptScore W2408103693C2777628954 @default.
- W2408103693 hasConceptScore W2408103693C2781024287 @default.
- W2408103693 hasConceptScore W2408103693C2781080829 @default.
- W2408103693 hasConceptScore W2408103693C71924100 @default.
- W2408103693 hasConceptScore W2408103693C86803240 @default.
- W2408103693 hasConceptScore W2408103693C89560881 @default.
- W2408103693 hasLocation W24081036931 @default.
- W2408103693 hasOpenAccess W2408103693 @default.
- W2408103693 hasPrimaryLocation W24081036931 @default.
- W2408103693 hasRelatedWork W1978306409 @default.
- W2408103693 hasRelatedWork W1989464596 @default.
- W2408103693 hasRelatedWork W1995279481 @default.
- W2408103693 hasRelatedWork W2010147800 @default.
- W2408103693 hasRelatedWork W2021403302 @default.
- W2408103693 hasRelatedWork W2035637315 @default.
- W2408103693 hasRelatedWork W2049790933 @default.
- W2408103693 hasRelatedWork W2056629177 @default.
- W2408103693 hasRelatedWork W2060366462 @default.
- W2408103693 hasRelatedWork W2060599853 @default.
- W2408103693 hasRelatedWork W2074490666 @default.
- W2408103693 hasRelatedWork W2085871809 @default.
- W2408103693 hasRelatedWork W2091616156 @default.
- W2408103693 hasRelatedWork W2125389594 @default.
- W2408103693 hasRelatedWork W2152691151 @default.
- W2408103693 hasRelatedWork W2246347275 @default.
- W2408103693 hasRelatedWork W2409190100 @default.
- W2408103693 hasRelatedWork W2423731072 @default.
- W2408103693 hasRelatedWork W3144063283 @default.
- W2408103693 hasRelatedWork W3146467488 @default.
- W2408103693 isParatext "false" @default.
- W2408103693 isRetracted "false" @default.
- W2408103693 magId "2408103693" @default.
- W2408103693 workType "article" @default.