Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408154948> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2408154948 endingPage "R832" @default.
- W2408154948 startingPage "R824" @default.
- W2408154948 abstract "Peripheral- and central nervous system (CNS)-mediated effects of desipramine (Des) on sympathetic nerves and the contribution of alpha 2-adrenoceptors to these effects were studied in conscious rabbits. Blood pressure, renal sympathetic nerve activity (SNA), and norepinephrine (NE) reuptake and spillover into plasma were measured before and after intracisternal (ic) or intravenous (i.v.) administration of Des. In other animals, NE spillover responses to i.v. Des were examined before and after alpha 2-adrenoceptor blockade with i.v. idazoxan. Treatment with i.v. Des blocked neuronal reuptake and decreased renal SNA but did not alter blood pressure or NE spillover. Decreased NE release by sympathetic nerves after i.v. Des was reflected by a decrease in the combined rate of NE reuptake and spillover. Treatment with ic Des (at 1.7% of the i.v. dose) decreased blood pressure and renal SNA and produced equivalent falls in NE reuptake and spillover, indicating little peripheral effect of centrally administered Des on the efficiency of neuronal reuptake. Thus Des had two distinct actions: the drug blocked neuronal reuptake by direct actions on nerve endings and reduced SNA by actions within the CNS. After ic Des, decreased SNA produced parallel falls in NE reuptake, spillover, and blood pressure. After i.v. Des, blockade of neurotransmitter reuptake increased NE concentrations at sympathoeffector junctions offsetting the fall in SNA, so that there was little change in NE spillover or blood pressure. However, after alpha 2-adrenoceptor blockade with i.v. idazoxan, NE spillover increased in response to i.v. Des. Thus the Des-induced decrease in NE release was partly mediated by an action of raised intrasynaptic NE concentrations on inhibitory alpha 2-adrenoceptors." @default.
- W2408154948 created "2016-06-24" @default.
- W2408154948 creator A5011375886 @default.
- W2408154948 creator A5030737904 @default.
- W2408154948 creator A5039727606 @default.
- W2408154948 creator A5043471986 @default.
- W2408154948 creator A5046768397 @default.
- W2408154948 creator A5073607570 @default.
- W2408154948 date "1991-04-01" @default.
- W2408154948 modified "2023-09-26" @default.
- W2408154948 title "Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbits" @default.
- W2408154948 doi "https://doi.org/10.1152/ajpregu.1991.260.4.r824" @default.
- W2408154948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1672797" @default.
- W2408154948 hasPublicationYear "1991" @default.
- W2408154948 type Work @default.
- W2408154948 sameAs 2408154948 @default.
- W2408154948 citedByCount "29" @default.
- W2408154948 countsByYear W24081549482012 @default.
- W2408154948 countsByYear W24081549482015 @default.
- W2408154948 countsByYear W24081549482017 @default.
- W2408154948 countsByYear W24081549482019 @default.
- W2408154948 crossrefType "journal-article" @default.
- W2408154948 hasAuthorship W2408154948A5011375886 @default.
- W2408154948 hasAuthorship W2408154948A5030737904 @default.
- W2408154948 hasAuthorship W2408154948A5039727606 @default.
- W2408154948 hasAuthorship W2408154948A5043471986 @default.
- W2408154948 hasAuthorship W2408154948A5046768397 @default.
- W2408154948 hasAuthorship W2408154948A5073607570 @default.
- W2408154948 hasConcept C126322002 @default.
- W2408154948 hasConcept C134018914 @default.
- W2408154948 hasConcept C170493617 @default.
- W2408154948 hasConcept C185592680 @default.
- W2408154948 hasConcept C2775864247 @default.
- W2408154948 hasConcept C2776533406 @default.
- W2408154948 hasConcept C2776885963 @default.
- W2408154948 hasConcept C2778468042 @default.
- W2408154948 hasConcept C2778514916 @default.
- W2408154948 hasConcept C2779177272 @default.
- W2408154948 hasConcept C2780250439 @default.
- W2408154948 hasConcept C2780648677 @default.
- W2408154948 hasConcept C2780939551 @default.
- W2408154948 hasConcept C2781161787 @default.
- W2408154948 hasConcept C31487548 @default.
- W2408154948 hasConcept C513476851 @default.
- W2408154948 hasConcept C71924100 @default.
- W2408154948 hasConcept C84393581 @default.
- W2408154948 hasConcept C98274493 @default.
- W2408154948 hasConcept C99631742 @default.
- W2408154948 hasConceptScore W2408154948C126322002 @default.
- W2408154948 hasConceptScore W2408154948C134018914 @default.
- W2408154948 hasConceptScore W2408154948C170493617 @default.
- W2408154948 hasConceptScore W2408154948C185592680 @default.
- W2408154948 hasConceptScore W2408154948C2775864247 @default.
- W2408154948 hasConceptScore W2408154948C2776533406 @default.
- W2408154948 hasConceptScore W2408154948C2776885963 @default.
- W2408154948 hasConceptScore W2408154948C2778468042 @default.
- W2408154948 hasConceptScore W2408154948C2778514916 @default.
- W2408154948 hasConceptScore W2408154948C2779177272 @default.
- W2408154948 hasConceptScore W2408154948C2780250439 @default.
- W2408154948 hasConceptScore W2408154948C2780648677 @default.
- W2408154948 hasConceptScore W2408154948C2780939551 @default.
- W2408154948 hasConceptScore W2408154948C2781161787 @default.
- W2408154948 hasConceptScore W2408154948C31487548 @default.
- W2408154948 hasConceptScore W2408154948C513476851 @default.
- W2408154948 hasConceptScore W2408154948C71924100 @default.
- W2408154948 hasConceptScore W2408154948C84393581 @default.
- W2408154948 hasConceptScore W2408154948C98274493 @default.
- W2408154948 hasConceptScore W2408154948C99631742 @default.
- W2408154948 hasIssue "4" @default.
- W2408154948 hasLocation W24081549481 @default.
- W2408154948 hasLocation W24081549482 @default.
- W2408154948 hasOpenAccess W2408154948 @default.
- W2408154948 hasPrimaryLocation W24081549481 @default.
- W2408154948 hasRelatedWork W1821519937 @default.
- W2408154948 hasRelatedWork W2004587509 @default.
- W2408154948 hasRelatedWork W2044619770 @default.
- W2408154948 hasRelatedWork W2044985824 @default.
- W2408154948 hasRelatedWork W2061201600 @default.
- W2408154948 hasRelatedWork W2071491126 @default.
- W2408154948 hasRelatedWork W2324925659 @default.
- W2408154948 hasRelatedWork W2408154948 @default.
- W2408154948 hasRelatedWork W2590800123 @default.
- W2408154948 hasRelatedWork W3043233501 @default.
- W2408154948 hasVolume "260" @default.
- W2408154948 isParatext "false" @default.
- W2408154948 isRetracted "false" @default.
- W2408154948 magId "2408154948" @default.
- W2408154948 workType "article" @default.