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- W2408184219 endingPage "165" @default.
- W2408184219 startingPage "157" @default.
- W2408184219 abstract "Circulating B cells must encounter cognate antigen to fulfill their unique function of producing high-affinity antibodies to combat infection. Secondary lymphoid organs (SLOs) provide the locus for antigen encounter, having a precise architecture that is tightly controlled by chemokine gradients. The properties of antigens dictate their route to B cell encounters. In the lymph node, small and soluble antigen arrives swiftly and reaches B cell follicles either through pores in the subcapsular sinus (SCS) or via a conduit system. Larger antigen and immune complexes are captured by SCS macrophages as they enter the lymph node either for presentation to cognate B cells or for shuttling by noncognate B cells to follicular dendritic cells (FDCs) for storage and presentation to cognate B cells. Later, waves of antigen arrive in the lymph node carried on migratory dendritic cells. The spleen specializes in eliminating blood-borne antigen. Here, a specialized B cell population in the marginal zone (MZ) shuttles antigen from the MZ to FDCs in white pulp follicles in an analogous mechanism to that of the lymph node. Importantly, SLO architecture can be disturbed as a consequence of pathogenic infection, leading to temporarily reduced responses to subsequent challenge." @default.
- W2408184219 created "2016-06-24" @default.
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- W2408184219 creator A5075647746 @default.
- W2408184219 creator A5087119573 @default.
- W2408184219 creator A5091187109 @default.
- W2408184219 date "2016-01-01" @default.
- W2408184219 modified "2023-10-18" @default.
- W2408184219 title "Antigen Acquisition In Vivo and its Role in B Cell Activation" @default.
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- W2408184219 doi "https://doi.org/10.1016/b978-0-12-374279-7.09002-0" @default.
- W2408184219 hasPublicationYear "2016" @default.
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