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• W2408313511 startingPage "270" @default.
• W2408313511 abstract "Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Chinese herbs, such as Cassia occidentalis, Rheum palmatum L., Aloe vera, and Polygonum multiflorum Thunb. Emerging evidence suggests that aloe-emodin exhibits many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. These pharmacological properties lay the foundation for the treatment of various diseases, including influenza virus, inflammation, sepsis, Alzheimer's disease, glaucoma, malaria, liver fibrosis, psoriasis, Type 2 diabetes, growth disorders, and several types of cancers. However, an increasing number of published studies have reported adverse effects of aloe-emodin. The primary toxicity among these reports is hepatotoxicity and nephrotoxicity, which are of wide concern worldwide. Pharmacokinetic studies have demonstrated that aloe-emodin has a poor intestinal absorption, short elimination half-life, and low bioavailability. This review aims to provide a comprehensive summary of the pharmacology, toxicity, and pharmacokinetics of aloe-emodin reported to date with an emphasis on its biological properties and mechanisms of action." @default.
• W2408313511 created "2016-06-24" @default.
• W2408313511 creator A5008659449 @default.
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• W2408313511 creator A5039593105 @default.
• W2408313511 creator A5064562340 @default.
• W2408313511 creator A5068644486 @default.
• W2408313511 date "2019-11-03" @default.
• W2408313511 modified "2023-10-18" @default.
• W2408313511 title "Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics" @default.
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• W2408313511 doi "https://doi.org/10.1002/ptr.6532" @default.

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