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• W2408446762 abstract "No AccessJournal of Urology1 Aug 1992The Predictive Value of Flow Cytometry and Urinary Cytology in the Followup of Patients with Transitional Cell Carcinoma of the Bladder John G. Giella, Kenneth Ring, Carl A. Olsson, Frieda S. Karp, and Mitchell C. Benson John G. GiellaJohn G. Giella More articles by this author , Kenneth RingKenneth Ring More articles by this author , Carl A. OlssonCarl A. Olsson More articles by this author , Frieda S. KarpFrieda S. Karp More articles by this author , and Mitchell C. BensonMitchell C. Benson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36576-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To determine the predictive value of flow cytometric deoxyribonucleic acid (DNA) ploidy and urine cytology in patients with superficial transitional cell carcinoma of the bladder, a retrospective analysis was performed on 181 patients who presented for evaluation of presumed superficial transitional cell carcinoma of the bladder. Of the patients 91 were confirmed to have superficial transitional cell carcinoma and were systematically followed with cystoscopy, flow cytometry and urine cytology from 1984 until 1989. They underwent 637 evaluations (mean 7 evaluations per patient). At initial evaluation, flow cytometry had 81% sensitivity and 57% specificity, while urine cytology was 75% sensitive and 94% specific. During the followup flow cytometry was 76% sensitive and 36% specific. Urine cytology was less sensitive (40%) but more specific (81%) than flow cytometry in followup evaluation. These results were similar whether intravesical chemotherapy or bacillus Calmette-Guerin was administered. To ascertain whether false positive flow cytometry represented early detection of recurrent transitional cell carcinoma not apparent at cystoscopy, patients with positive flow cytometry and urine cytology were followed longitudinally. False positive flow cytometry and urine cytology were equally predictive of recurrent transitional cell carcinoma progressively with time. However, for any given examination flow cytometry was more likely to detect and predict recurrent transitional cell carcinoma. At 4 years the bladder transitional cell carcinoma incidence for false positive flow cytometry and urine cytology was 87% and 84%, respectively. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited bySchmetter B, Habicht K, Lamm D, Morales A, Bander N, Grossman H, Hanna M, Silberman S and Butman B (2018) A Multicenter Trial Evaluation of the Fibrin/Fibrinogen Degradation Products Test for Detection and Monitoring of Bladder CancerJournal of Urology, VOL. 158, NO. 3, (801-805), Online publication date: 1-Sep-1997.Gregoire M, Fradet Y, Meyer F, Tetu B, Bois R, Bedard G, Charrois R and Naud A (2018) Diagnostic Accuracy of Urinary Cytology, and Deoxyribonucleic Acid Flow Cytometry and Cytology on Bladder Washings During Followup for Bladder TumorsJournal of Urology, VOL. 157, NO. 5, (1660-1664), Online publication date: 1-May-1997.Mora L, Nicosia S, Pow-Sang J, Ku N, Diaz J, Lockhart J and Einstein A (2018) Ancillary Techniques in the Followup of Transitional Cell Carcinoma: A Comparison of Cytology, Histology and Deoxyribonucleic Acid Image Analysis Cytometry in 91 PatientsJournal of Urology, VOL. 156, NO. 1, (49-55), Online publication date: 1-Jul-1996.Nativ O, Medalia O, Engelberg S, Raviv G and Aronson M (2018) Enhanced Cytologic Detection of Early Stage Mouse Bladder Tumor Following Induction of Uroepithelial Cell SheddingJournal of Urology, VOL. 152, NO. 1, (217-219), Online publication date: 1-Jul-1994. Volume 148Issue 2 Part 1August 1992Page: 293-296 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordscytologyflow cytometryDNAploidiesbladder neoplasmsMetricsAuthor Information John G. Giella More articles by this author Kenneth Ring More articles by this author Carl A. Olsson More articles by this author Frieda S. Karp More articles by this author Mitchell C. Benson More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2408446762 title "The Predictive Value of Flow Cytometry and Urinary Cytology in the Followup of Patients with Transitional Cell Carcinoma of the Bladder" @default.
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