Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408456666> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2408456666 endingPage "56" @default.
- W2408456666 startingPage "49" @default.
- W2408456666 abstract "Celastrus paniculatus seed oil, commonly known as Malkangni or Jyotishmati, was in use from time immemorial to treat brain related disorders. Celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. The present study was undertaken to evaluate the antidepressant-like effect of Celastrus paniculatus seed oil in unstressed mice and to explore its mechanism of action.The seed oil (50, 100, and 200 mg/kg, PO) and fluoxetine per se were administered for 14 successive days to Swiss young albino mice. On the 14(th) day, 60 min after drug administration, animals were subjected to Tail Suspension Test (TST) and Forced Swim Test (FST). The mechanism of action was also studied.The oil significantly decreased immobility period of mice in both tail suspension test and forced swim test, indicating its significant antidepressant-like activity. The efficacy was found to be comparable to fluoxetine (P<0.0001). ED50 value of celastrus seed oil using FST and TST were 17.38 and 31.62 mg/kg, respectively. The oil did not show any significant effect on locomotor activity. It significantly inhibited brain MAO-A activity and decreased plasma corticosterone levels. Sulpiride (selective D2-receptor antagonist), p-CPA (tryptophan hydroxylase inhibitor), and baclofen (GABAB agonist) significantly attenuated the oil-induced antidepressant-like effect, when assessed during TST.Celastrus paniculatus seed oil produced significant antidepressant-like effect in mice possibly through interaction with dopamine D2, serotonergic, and GABAB receptors; as well as inhibition of MAO-A activity and decrease in plasma corticosterone levels." @default.
- W2408456666 created "2016-06-24" @default.
- W2408456666 creator A5012122728 @default.
- W2408456666 creator A5038783791 @default.
- W2408456666 date "2016-01-01" @default.
- W2408456666 modified "2023-09-23" @default.
- W2408456666 title "Behavioral and Biochemical Evidences for Antidepressant-Like Activity of Celastrus Paniculatus Seed Oil in Mice." @default.
- W2408456666 cites W133736196 @default.
- W2408456666 cites W1528823084 @default.
- W2408456666 cites W1998360317 @default.
- W2408456666 cites W2005594217 @default.
- W2408456666 cites W2015984453 @default.
- W2408456666 cites W2026026067 @default.
- W2408456666 cites W20284704 @default.
- W2408456666 cites W2034234581 @default.
- W2408456666 cites W2035532470 @default.
- W2408456666 cites W2038679778 @default.
- W2408456666 cites W2046033957 @default.
- W2408456666 cites W2065234222 @default.
- W2408456666 cites W2066831309 @default.
- W2408456666 cites W2072052737 @default.
- W2408456666 cites W2083851081 @default.
- W2408456666 cites W2088735154 @default.
- W2408456666 cites W2112712523 @default.
- W2408456666 cites W2156774337 @default.
- W2408456666 cites W2197078876 @default.
- W2408456666 cites W2319900104 @default.
- W2408456666 cites W2418627755 @default.
- W2408456666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4892330" @default.
- W2408456666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27303599" @default.
- W2408456666 hasPublicationYear "2016" @default.
- W2408456666 type Work @default.
- W2408456666 sameAs 2408456666 @default.
- W2408456666 citedByCount "6" @default.
- W2408456666 countsByYear W24084566662018 @default.
- W2408456666 countsByYear W24084566662019 @default.
- W2408456666 countsByYear W24084566662020 @default.
- W2408456666 countsByYear W24084566662021 @default.
- W2408456666 countsByYear W24084566662023 @default.
- W2408456666 crossrefType "journal-article" @default.
- W2408456666 hasAuthorship W2408456666A5012122728 @default.
- W2408456666 hasAuthorship W2408456666A5038783791 @default.
- W2408456666 hasConcept C134018914 @default.
- W2408456666 hasConcept C136569192 @default.
- W2408456666 hasConcept C170493617 @default.
- W2408456666 hasConcept C185592680 @default.
- W2408456666 hasConcept C2779177272 @default.
- W2408456666 hasConcept C2780352252 @default.
- W2408456666 hasConcept C2781001258 @default.
- W2408456666 hasConcept C2781161787 @default.
- W2408456666 hasConcept C42533223 @default.
- W2408456666 hasConcept C55493867 @default.
- W2408456666 hasConcept C71315377 @default.
- W2408456666 hasConcept C71924100 @default.
- W2408456666 hasConcept C98274493 @default.
- W2408456666 hasConceptScore W2408456666C134018914 @default.
- W2408456666 hasConceptScore W2408456666C136569192 @default.
- W2408456666 hasConceptScore W2408456666C170493617 @default.
- W2408456666 hasConceptScore W2408456666C185592680 @default.
- W2408456666 hasConceptScore W2408456666C2779177272 @default.
- W2408456666 hasConceptScore W2408456666C2780352252 @default.
- W2408456666 hasConceptScore W2408456666C2781001258 @default.
- W2408456666 hasConceptScore W2408456666C2781161787 @default.
- W2408456666 hasConceptScore W2408456666C42533223 @default.
- W2408456666 hasConceptScore W2408456666C55493867 @default.
- W2408456666 hasConceptScore W2408456666C71315377 @default.
- W2408456666 hasConceptScore W2408456666C71924100 @default.
- W2408456666 hasConceptScore W2408456666C98274493 @default.
- W2408456666 hasIssue "1" @default.
- W2408456666 hasLocation W24084566661 @default.
- W2408456666 hasOpenAccess W2408456666 @default.
- W2408456666 hasPrimaryLocation W24084566661 @default.
- W2408456666 hasRelatedWork W1963565991 @default.
- W2408456666 hasRelatedWork W1964192948 @default.
- W2408456666 hasRelatedWork W1984511502 @default.
- W2408456666 hasRelatedWork W1987222018 @default.
- W2408456666 hasRelatedWork W2031210349 @default.
- W2408456666 hasRelatedWork W2046033957 @default.
- W2408456666 hasRelatedWork W2114795231 @default.
- W2408456666 hasRelatedWork W2353197136 @default.
- W2408456666 hasRelatedWork W2383865056 @default.
- W2408456666 hasRelatedWork W2407457728 @default.
- W2408456666 hasVolume "7" @default.
- W2408456666 isParatext "false" @default.
- W2408456666 isRetracted "false" @default.
- W2408456666 magId "2408456666" @default.
- W2408456666 workType "article" @default.