Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408548412> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2408548412 endingPage "321" @default.
- W2408548412 startingPage "309" @default.
- W2408548412 abstract "Gene therapy of inherited diseases requires long-term maintenance of the corrective transgene. Stable integration of the introduced DNA molecule into one of the host cell chromosomes is the simplest strategy for achieving this. However, genotoxicity resulting from random insertion of the transgene raises serious safety concerns that must be addressed if gene therapy is to enter the clinical mainstream. The following method makes use of the Rep integrase of adeno-associated virus to insert a transgene into the human AAVS1 site, a known safe harbor region within the human genome. This approach has the potential for application to novel gene therapy strategies for improved safety. In addition, with this method it is also possible to create cell lines carrying BAC transgenes in the AAVS1 site." @default.
- W2408548412 created "2016-06-24" @default.
- W2408548412 creator A5017440633 @default.
- W2408548412 creator A5033965456 @default.
- W2408548412 creator A5086359347 @default.
- W2408548412 date "2014-09-03" @default.
- W2408548412 modified "2023-09-23" @default.
- W2408548412 title "Site-specific Integration of Bacterial Artificial Chromosomes into Human Cells" @default.
- W2408548412 cites W1583992601 @default.
- W2408548412 cites W1975890439 @default.
- W2408548412 cites W1977955083 @default.
- W2408548412 cites W1978290943 @default.
- W2408548412 cites W1996749102 @default.
- W2408548412 cites W2004938258 @default.
- W2408548412 cites W2008331547 @default.
- W2408548412 cites W2026652568 @default.
- W2408548412 cites W2070078486 @default.
- W2408548412 cites W2087528421 @default.
- W2408548412 cites W2105679399 @default.
- W2408548412 cites W2107046588 @default.
- W2408548412 cites W2137440275 @default.
- W2408548412 cites W2151604046 @default.
- W2408548412 cites W2157466002 @default.
- W2408548412 cites W2161341811 @default.
- W2408548412 cites W4323238558 @default.
- W2408548412 doi "https://doi.org/10.1007/978-1-4939-1652-8_17" @default.
- W2408548412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25239755" @default.
- W2408548412 hasPublicationYear "2014" @default.
- W2408548412 type Work @default.
- W2408548412 sameAs 2408548412 @default.
- W2408548412 citedByCount "0" @default.
- W2408548412 crossrefType "book-chapter" @default.
- W2408548412 hasAuthorship W2408548412A5017440633 @default.
- W2408548412 hasAuthorship W2408548412A5033965456 @default.
- W2408548412 hasAuthorship W2408548412A5086359347 @default.
- W2408548412 hasConcept C102230213 @default.
- W2408548412 hasConcept C104317684 @default.
- W2408548412 hasConcept C111599444 @default.
- W2408548412 hasConcept C127413603 @default.
- W2408548412 hasConcept C132144397 @default.
- W2408548412 hasConcept C141231307 @default.
- W2408548412 hasConcept C14430832 @default.
- W2408548412 hasConcept C2780098074 @default.
- W2408548412 hasConcept C30481170 @default.
- W2408548412 hasConcept C54355233 @default.
- W2408548412 hasConcept C552990157 @default.
- W2408548412 hasConcept C70721500 @default.
- W2408548412 hasConcept C78519656 @default.
- W2408548412 hasConcept C86803240 @default.
- W2408548412 hasConceptScore W2408548412C102230213 @default.
- W2408548412 hasConceptScore W2408548412C104317684 @default.
- W2408548412 hasConceptScore W2408548412C111599444 @default.
- W2408548412 hasConceptScore W2408548412C127413603 @default.
- W2408548412 hasConceptScore W2408548412C132144397 @default.
- W2408548412 hasConceptScore W2408548412C141231307 @default.
- W2408548412 hasConceptScore W2408548412C14430832 @default.
- W2408548412 hasConceptScore W2408548412C2780098074 @default.
- W2408548412 hasConceptScore W2408548412C30481170 @default.
- W2408548412 hasConceptScore W2408548412C54355233 @default.
- W2408548412 hasConceptScore W2408548412C552990157 @default.
- W2408548412 hasConceptScore W2408548412C70721500 @default.
- W2408548412 hasConceptScore W2408548412C78519656 @default.
- W2408548412 hasConceptScore W2408548412C86803240 @default.
- W2408548412 hasLocation W24085484121 @default.
- W2408548412 hasLocation W24085484122 @default.
- W2408548412 hasOpenAccess W2408548412 @default.
- W2408548412 hasPrimaryLocation W24085484121 @default.
- W2408548412 hasRelatedWork W1442603624 @default.
- W2408548412 hasRelatedWork W2003922337 @default.
- W2408548412 hasRelatedWork W2020194276 @default.
- W2408548412 hasRelatedWork W2069184423 @default.
- W2408548412 hasRelatedWork W2110447214 @default.
- W2408548412 hasRelatedWork W2408548412 @default.
- W2408548412 hasRelatedWork W2975451038 @default.
- W2408548412 hasRelatedWork W4315640719 @default.
- W2408548412 hasRelatedWork W2094069166 @default.
- W2408548412 hasRelatedWork W2187207551 @default.
- W2408548412 isParatext "false" @default.
- W2408548412 isRetracted "false" @default.
- W2408548412 magId "2408548412" @default.
- W2408548412 workType "book-chapter" @default.