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- W2408624464 abstract "The systolic and diastolic pressures in anesthetized Sprague-Dawley male rats were greatly decreased after single-dose of Cd treatment without significant changes in heart rate. There was a fluid-shift into the third space and/or -loss through the kidney, since plasma concentration and hematocrit ratio were significantly increased by acute Cd exposure. The present study showed that the sustained hypotensive effect of single-dose Cd on the cardiovascular system might have resulted from the systemic hypovolemia. Furthermore, renal excretion of electrolytes, including and , and urine flow rate were increased by Cd intoxication. Interestingly, the ratio of excretion was increased and reached the maximum level 3 hours after Cd injection and returned to the normal level after 7 hours. Nevertheless, there was no difference in the regression analysis of excretion and urine flow rate in both groups. Therefore, the increase in the urine volume seemed to enhance the excretion of . This study strongly suggest that the hypotensive effect of Cd is mediated by systemic loss through the kidney and/or hypovolemia via fluid-shift." @default.
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- W2408624464 date "2006-01-01" @default.
- W2408624464 modified "2023-09-27" @default.
- W2408624464 title "Changes of Hemodynamics and Renal Function due to Acute Cadmium Exposure in Rats" @default.
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