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- W2408751856 abstract "Transforming growth factor-β (TGF-β) superfamily controls many physiological processes such as cell proliferation and differentiation, immune responses, wound repair and various endocrine activities. As a member of TGF-β, activin A can maintain the pluripotency of embryonic stem cells. We report here that activin A exhibited cell type-dependent function of expanding the human primitive hematopoietic cells isolated from umbilical cord blood (UCB). However, the multipotency of the cells pretreated with activin A was exhausted in the sequential dilution culture. In conclusion, activin A may not be a key factor, but a regulator, in the multipotency maintenance of primitive hematopoietic cells and the application of activin A in the hematopoietic stem/progenitor cells (HS/PCs) culture expansion remains a significant challenge." @default.
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- W2408751856 date "2012-12-01" @default.
- W2408751856 modified "2023-09-27" @default.
- W2408751856 title "Characterization of activin A in the culture of primitive human umbilical cord blood hematopoietic cells" @default.
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- W2408751856 doi "https://doi.org/10.1016/j.biopha.2012.08.007" @default.
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