Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408778847> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2408778847 endingPage "180" @default.
- W2408778847 startingPage "169" @default.
- W2408778847 abstract "Aberrant expression of receptor tyrosine kinases (RTKs) has been extensively associated with alterations in the physiological activities of cells. These include cell growth and differentiation, cell death/survival, and the motility of cells which can subsequently lead to emergence of various diseases including cancer. Recent advances in the treatment of cancer have involved using RTKs as therapeutic targets. Unfortunately, the clinical use of receptor tyrosine kinase inhibitors (RTKIs) for the treatment of cancer has been hindered by innate or acquired resistance among some patients, as also experienced with classical chemotherapy. It has become apparent that the deregulated expression of RTKs may play a significant part in driving this resistance. In order to fully elucidate the role of RTKs in drug resistance, the use of preclinical models has helped to mimic this clinical problem. In this chapter, we describe the methods associated with establishing and characterizing cell line models of drug resistance to the dual RTKI, lapatinib. These methods include the assessment of lapatinib resistance; cross-resistance to other RTKIs; the alteration of RTK expression; and other associated phenotypic changes such as cellular migration, invasion, and anoikis sensitivity/resistance." @default.
- W2408778847 created "2016-06-24" @default.
- W2408778847 creator A5025907836 @default.
- W2408778847 creator A5068225035 @default.
- W2408778847 date "2014-10-01" @default.
- W2408778847 modified "2023-10-17" @default.
- W2408778847 title "Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors" @default.
- W2408778847 cites W1972741145 @default.
- W2408778847 cites W1979702889 @default.
- W2408778847 cites W2022622162 @default.
- W2408778847 cites W2028415754 @default.
- W2408778847 cites W2032397471 @default.
- W2408778847 cites W2033795441 @default.
- W2408778847 cites W2054020870 @default.
- W2408778847 cites W2074136156 @default.
- W2408778847 cites W2076295610 @default.
- W2408778847 cites W2098544382 @default.
- W2408778847 cites W2109242805 @default.
- W2408778847 cites W2129110050 @default.
- W2408778847 cites W2129837161 @default.
- W2408778847 cites W2142776762 @default.
- W2408778847 cites W2145139438 @default.
- W2408778847 cites W2145824104 @default.
- W2408778847 cites W2147032433 @default.
- W2408778847 cites W2149106642 @default.
- W2408778847 cites W2154349915 @default.
- W2408778847 cites W2157158866 @default.
- W2408778847 cites W2158927987 @default.
- W2408778847 cites W2159569733 @default.
- W2408778847 doi "https://doi.org/10.1007/978-1-4939-1789-1_16" @default.
- W2408778847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25319899" @default.
- W2408778847 hasPublicationYear "2014" @default.
- W2408778847 type Work @default.
- W2408778847 sameAs 2408778847 @default.
- W2408778847 citedByCount "8" @default.
- W2408778847 countsByYear W24087788472018 @default.
- W2408778847 countsByYear W24087788472019 @default.
- W2408778847 countsByYear W24087788472021 @default.
- W2408778847 countsByYear W24087788472022 @default.
- W2408778847 countsByYear W24087788472023 @default.
- W2408778847 crossrefType "book-chapter" @default.
- W2408778847 hasAuthorship W2408778847A5025907836 @default.
- W2408778847 hasAuthorship W2408778847A5068225035 @default.
- W2408778847 hasBestOaLocation W24087788472 @default.
- W2408778847 hasConcept C101544691 @default.
- W2408778847 hasConcept C114851261 @default.
- W2408778847 hasConcept C121608353 @default.
- W2408778847 hasConcept C152000582 @default.
- W2408778847 hasConcept C2777329042 @default.
- W2408778847 hasConcept C2779786085 @default.
- W2408778847 hasConcept C42362537 @default.
- W2408778847 hasConcept C502942594 @default.
- W2408778847 hasConcept C530470458 @default.
- W2408778847 hasConcept C54355233 @default.
- W2408778847 hasConcept C62478195 @default.
- W2408778847 hasConcept C86803240 @default.
- W2408778847 hasConcept C95444343 @default.
- W2408778847 hasConcept C96232424 @default.
- W2408778847 hasConcept C98274493 @default.
- W2408778847 hasConceptScore W2408778847C101544691 @default.
- W2408778847 hasConceptScore W2408778847C114851261 @default.
- W2408778847 hasConceptScore W2408778847C121608353 @default.
- W2408778847 hasConceptScore W2408778847C152000582 @default.
- W2408778847 hasConceptScore W2408778847C2777329042 @default.
- W2408778847 hasConceptScore W2408778847C2779786085 @default.
- W2408778847 hasConceptScore W2408778847C42362537 @default.
- W2408778847 hasConceptScore W2408778847C502942594 @default.
- W2408778847 hasConceptScore W2408778847C530470458 @default.
- W2408778847 hasConceptScore W2408778847C54355233 @default.
- W2408778847 hasConceptScore W2408778847C62478195 @default.
- W2408778847 hasConceptScore W2408778847C86803240 @default.
- W2408778847 hasConceptScore W2408778847C95444343 @default.
- W2408778847 hasConceptScore W2408778847C96232424 @default.
- W2408778847 hasConceptScore W2408778847C98274493 @default.
- W2408778847 hasLocation W24087788471 @default.
- W2408778847 hasLocation W24087788472 @default.
- W2408778847 hasLocation W24087788473 @default.
- W2408778847 hasOpenAccess W2408778847 @default.
- W2408778847 hasPrimaryLocation W24087788471 @default.
- W2408778847 hasRelatedWork W178368023 @default.
- W2408778847 hasRelatedWork W2027911638 @default.
- W2408778847 hasRelatedWork W2029323837 @default.
- W2408778847 hasRelatedWork W2150814991 @default.
- W2408778847 hasRelatedWork W2160930114 @default.
- W2408778847 hasRelatedWork W2320148073 @default.
- W2408778847 hasRelatedWork W2321063763 @default.
- W2408778847 hasRelatedWork W2348792217 @default.
- W2408778847 hasRelatedWork W284991352 @default.
- W2408778847 hasRelatedWork W2955213075 @default.
- W2408778847 isParatext "false" @default.
- W2408778847 isRetracted "false" @default.
- W2408778847 magId "2408778847" @default.
- W2408778847 workType "book-chapter" @default.