Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408834279> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2408834279 endingPage "541" @default.
- W2408834279 startingPage "531" @default.
- W2408834279 abstract "1. Presynaptic activity in the inhibitory network impinging on the Mauthner (M-) cell was investigated in the goldfish medulla in vivo using extra- and intracellular recordings. The inhibitory presynaptic volley elicited by stimulation of the contralateral vestibular nerve consisted of multiple successive peaks at high frequency (up to 1,000 Hz). Less pronounced multicomponent responses were recorded after antidromic activation of the M-cell. Such high-frequency oscillatory field potentials also occurred spontaneously. 2. In intracellular recordings, a subset of inhibitory interneurons showed evoked and spontaneous burst discharge. Burst action potentials were correlated with the peaks in the extracellular volley, suggesting that repetitive firing of these cells is synchronized. Nonbursting cells, on the other hand, fired single action potentials in response to vestibular stimuli and were not activated via the M-cell collateral network. 3. Bursting cells were determined morphologically to be part of the feedback inhibitory circuit. Their responses to stimulation of the contralateral vestibular nerve thus suggest the existence of a crossed excitatory pathway to these interneurons. 4. Vestibular-evoked excitatory postsynaptic potentials (EPSPs) in bursting interneurons had a short latency of 0.781 +/- 0.08 ms (mean +/- SD, n = 18) but reached threshold at 2.25 +/- 1 ms (n = 21). These characteristics are suggestive of a chemically mediated EPSP. Indeed, the evoked synchronous repetitive activity of these cells was prevented by superfusion with excitatory amino-acid receptor antagonists. 5. Bursting neurons showed several characteristics that differentiate them from nonbursting cells, including brief action potentials, plateau responses, and intense spontaneous subthreshold activity. 6. With extracellular recordings, tetanization of contralateral vestibular primary afferents evoked a long-lasting potentiation of oscillatory population responses in 11 of 27 cases. Furthermore in three experiments, the frequency of occurrence of spontaneous bursts was enhanced and a similar facilitation was detected at the intracellular level. 7. We conclude that a subset of interneurons in this inhibitory network is capable of repetitive discharges and that evoked as well as spontaneous firing in this population is synchronized. Although electrical coupling between interneurons may mediate synchronization and intrinsic membrane properties may promote burst activity, our data suggest strongly that repetitive firing requires chemically mediated transmission. Furthermore they indicate that the mechanisms underlying evoked as well as spontaneous bursting in this population show activity-dependent plasticity." @default.
- W2408834279 created "2016-06-24" @default.
- W2408834279 creator A5003936492 @default.
- W2408834279 creator A5015906585 @default.
- W2408834279 creator A5029844345 @default.
- W2408834279 creator A5039378309 @default.
- W2408834279 creator A5069754470 @default.
- W2408834279 date "1994-08-01" @default.
- W2408834279 modified "2023-10-04" @default.
- W2408834279 title "Synchronous bursting in a subset of interneurons inhibitory to the goldfish Mauthner cell: synaptic mediation and plasticity" @default.
- W2408834279 doi "https://doi.org/10.1152/jn.1994.72.2.531" @default.
- W2408834279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7983517" @default.
- W2408834279 hasPublicationYear "1994" @default.
- W2408834279 type Work @default.
- W2408834279 sameAs 2408834279 @default.
- W2408834279 citedByCount "13" @default.
- W2408834279 countsByYear W24088342792012 @default.
- W2408834279 countsByYear W24088342792017 @default.
- W2408834279 countsByYear W24088342792019 @default.
- W2408834279 crossrefType "journal-article" @default.
- W2408834279 hasAuthorship W2408834279A5003936492 @default.
- W2408834279 hasAuthorship W2408834279A5015906585 @default.
- W2408834279 hasAuthorship W2408834279A5029844345 @default.
- W2408834279 hasAuthorship W2408834279A5039378309 @default.
- W2408834279 hasAuthorship W2408834279A5069754470 @default.
- W2408834279 hasConcept C112592302 @default.
- W2408834279 hasConcept C169760540 @default.
- W2408834279 hasConcept C170493617 @default.
- W2408834279 hasConcept C17077164 @default.
- W2408834279 hasConcept C185263204 @default.
- W2408834279 hasConcept C185592680 @default.
- W2408834279 hasConcept C195221683 @default.
- W2408834279 hasConcept C197341189 @default.
- W2408834279 hasConcept C24998067 @default.
- W2408834279 hasConcept C2779296341 @default.
- W2408834279 hasConcept C55493867 @default.
- W2408834279 hasConcept C70471684 @default.
- W2408834279 hasConcept C86803240 @default.
- W2408834279 hasConceptScore W2408834279C112592302 @default.
- W2408834279 hasConceptScore W2408834279C169760540 @default.
- W2408834279 hasConceptScore W2408834279C170493617 @default.
- W2408834279 hasConceptScore W2408834279C17077164 @default.
- W2408834279 hasConceptScore W2408834279C185263204 @default.
- W2408834279 hasConceptScore W2408834279C185592680 @default.
- W2408834279 hasConceptScore W2408834279C195221683 @default.
- W2408834279 hasConceptScore W2408834279C197341189 @default.
- W2408834279 hasConceptScore W2408834279C24998067 @default.
- W2408834279 hasConceptScore W2408834279C2779296341 @default.
- W2408834279 hasConceptScore W2408834279C55493867 @default.
- W2408834279 hasConceptScore W2408834279C70471684 @default.
- W2408834279 hasConceptScore W2408834279C86803240 @default.
- W2408834279 hasIssue "2" @default.
- W2408834279 hasLocation W24088342791 @default.
- W2408834279 hasLocation W24088342792 @default.
- W2408834279 hasOpenAccess W2408834279 @default.
- W2408834279 hasPrimaryLocation W24088342791 @default.
- W2408834279 hasRelatedWork W1542191210 @default.
- W2408834279 hasRelatedWork W1970818849 @default.
- W2408834279 hasRelatedWork W2027265904 @default.
- W2408834279 hasRelatedWork W2094353622 @default.
- W2408834279 hasRelatedWork W2143719848 @default.
- W2408834279 hasRelatedWork W2289094269 @default.
- W2408834279 hasRelatedWork W2408834279 @default.
- W2408834279 hasRelatedWork W2752743978 @default.
- W2408834279 hasRelatedWork W2974026767 @default.
- W2408834279 hasRelatedWork W3093008590 @default.
- W2408834279 hasVolume "72" @default.
- W2408834279 isParatext "false" @default.
- W2408834279 isRetracted "false" @default.
- W2408834279 magId "2408834279" @default.
- W2408834279 workType "article" @default.