Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408881079> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2408881079 endingPage "65" @default.
- W2408881079 startingPage "3159" @default.
- W2408881079 abstract "We recently isolated and characterized a tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), which inhibits proliferation of lymphoid cells. In this paper we describe the effects of Ac-ESG on growth-related gene expression and cell cycle progression in two lymphoma cell lines, Ramos and Molt, representing B and T lymphocytes, respectively.RNA was extracted from Molt and Ramos cells with or without the tripeptide treatment. Gene expression was examined by semi-quantitative RT-PCR and Northern blot hybridization, and cell cycle progression was detected by flow cytometry.In the Molt cells, p53 gene expression was increased following treatment while c-myc was decreased after treatment shorter than 24 hours; N-ras expression was significantly reduced at picomolar concentration for 24-hour treatment; cyclinD1 and cdk4 expression did not show any change; DNA flow cytometry demonstrated that Molt cells were arrested or delayed predominantly in G2-M. Untreated Ramos cells had higher gene expression levels of c-myc, N-Ras and cdk4 than Molt cells, but lower p53 expression. These cells were not sensitive to Ac-ESG.The tripeptide Ac-ESG alters the expression of several growth-related genes in the Molt cell line and brings about an arrest or delay of cells in G2-M." @default.
- W2408881079 created "2016-06-24" @default.
- W2408881079 creator A5004080827 @default.
- W2408881079 creator A5025536551 @default.
- W2408881079 creator A5026627210 @default.
- W2408881079 creator A5034633031 @default.
- W2408881079 creator A5076530600 @default.
- W2408881079 date "2003-08-21" @default.
- W2408881079 modified "2023-09-27" @default.
- W2408881079 title "The effects of a growth-inhibiting tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), on gene expression and cell cycle progression of two lymphoma cell lines." @default.
- W2408881079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12926049" @default.
- W2408881079 hasPublicationYear "2003" @default.
- W2408881079 type Work @default.
- W2408881079 sameAs 2408881079 @default.
- W2408881079 citedByCount "1" @default.
- W2408881079 countsByYear W24088810792012 @default.
- W2408881079 crossrefType "journal-article" @default.
- W2408881079 hasAuthorship W2408881079A5004080827 @default.
- W2408881079 hasAuthorship W2408881079A5025536551 @default.
- W2408881079 hasAuthorship W2408881079A5026627210 @default.
- W2408881079 hasAuthorship W2408881079A5034633031 @default.
- W2408881079 hasAuthorship W2408881079A5076530600 @default.
- W2408881079 hasConcept C104317684 @default.
- W2408881079 hasConcept C150194340 @default.
- W2408881079 hasConcept C153911025 @default.
- W2408881079 hasConcept C177707886 @default.
- W2408881079 hasConcept C203014093 @default.
- W2408881079 hasConcept C2779338263 @default.
- W2408881079 hasConcept C29537977 @default.
- W2408881079 hasConcept C502942594 @default.
- W2408881079 hasConcept C54355233 @default.
- W2408881079 hasConcept C553184892 @default.
- W2408881079 hasConcept C55493867 @default.
- W2408881079 hasConcept C62112901 @default.
- W2408881079 hasConcept C81885089 @default.
- W2408881079 hasConcept C86803240 @default.
- W2408881079 hasConceptScore W2408881079C104317684 @default.
- W2408881079 hasConceptScore W2408881079C150194340 @default.
- W2408881079 hasConceptScore W2408881079C153911025 @default.
- W2408881079 hasConceptScore W2408881079C177707886 @default.
- W2408881079 hasConceptScore W2408881079C203014093 @default.
- W2408881079 hasConceptScore W2408881079C2779338263 @default.
- W2408881079 hasConceptScore W2408881079C29537977 @default.
- W2408881079 hasConceptScore W2408881079C502942594 @default.
- W2408881079 hasConceptScore W2408881079C54355233 @default.
- W2408881079 hasConceptScore W2408881079C553184892 @default.
- W2408881079 hasConceptScore W2408881079C55493867 @default.
- W2408881079 hasConceptScore W2408881079C62112901 @default.
- W2408881079 hasConceptScore W2408881079C81885089 @default.
- W2408881079 hasConceptScore W2408881079C86803240 @default.
- W2408881079 hasIssue "4" @default.
- W2408881079 hasLocation W24088810791 @default.
- W2408881079 hasOpenAccess W2408881079 @default.
- W2408881079 hasPrimaryLocation W24088810791 @default.
- W2408881079 hasRelatedWork W2008317297 @default.
- W2408881079 hasRelatedWork W2350231700 @default.
- W2408881079 hasRelatedWork W2355897695 @default.
- W2408881079 hasRelatedWork W2357329258 @default.
- W2408881079 hasRelatedWork W2362501009 @default.
- W2408881079 hasRelatedWork W2374592133 @default.
- W2408881079 hasRelatedWork W2378203004 @default.
- W2408881079 hasRelatedWork W2387175565 @default.
- W2408881079 hasRelatedWork W2408881079 @default.
- W2408881079 hasRelatedWork W3030640751 @default.
- W2408881079 hasVolume "23" @default.
- W2408881079 isParatext "false" @default.
- W2408881079 isRetracted "false" @default.
- W2408881079 magId "2408881079" @default.
- W2408881079 workType "article" @default.