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• W2408908504 abstract "Although biodegradable amphiphilic block copolymer micelles have been widely applied in the clinical applications as drug delivery nanocarriers, low-efficiency cellular internalization frequently reduces therapeutic efficacy of the loaded drugs. Here, photothermal effect-promoted cellular internalization of finely tuned thermo-responsive amphiphilic biodegradable block copolymer nanocarriers via noninvasive stimuli of near-infrared (NIR) light irradiation is demonstrated. Amphiphilic block copolymers, poly(ε-caprolactone)-block-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (PCL-b-P(NIPAM-co-DMA)), are prepared with finely tuned compositions of P(NIPAM-co-DMA) for desirable lower critical solution temperature of the block copolymer micelles in aqueous solution. The block copolymers are then used to co-encapsulate doxorubicin and indocyanine green, which show high encapsulation efficiency and significant photothermal effect upon exposure to NIR light irradiation. The photothermal effect-induced collapse and hydrophilic-to-hydrophobic transition of P(NIPAM-co-DMA) shells significantly enhance the interactions between drug-loaded micelles and cell membranes, which dramatically promote the cellular internalization of the micelles and therapeutic efficacy of loaded anticancer drugs." @default.
• W2408908504 created "2016-06-24" @default.
• W2408908504 creator A5012951732 @default.
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• W2408908504 date "2016-06-08" @default.
• W2408908504 modified "2023-10-12" @default.
• W2408908504 title "Finely Tuned Thermo-Responsive Block Copolymer Micelles for Photothermal Effect-Triggered Efficient Cellular Internalization" @default.
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• W2408908504 doi "https://doi.org/10.1002/mabi.201600119" @default.
• W2408908504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27273364" @default.
• W2408908504 hasPublicationYear "2016" @default.
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