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- W2408909287 abstract "In 6 patients with cirrhosis at the liver and 5 control patients, the serum concentrations of phenylbutazone (pbz) and a major metabolite, oxphenylbutazone (ox-pbz), were followed for 16 days after oral administration of fixed doses of pbz for 4 days (600, 600,300,300 mg). Preliminary evidence is presented for a significant correlation between the apparent elimination rate constant of pbz (the plasma half-life) and the galactose elimination capacity (r = 0.868, P < 0.05) in cirrhotic patients. The ratio between the peak concentrations at pbz and ox-pbz in the two groups was not different." @default.
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- W2408909287 date "1974-02-01" @default.
- W2408909287 modified "2023-09-27" @default.
- W2408909287 title "Plasma half-life of phenylbutazone in patients with impaired liver function" @default.
- W2408909287 doi "https://doi.org/10.1002/cpt1974152171" @default.
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