FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408937128> ?p ?o ?g. }

• W2408937128 endingPage "9" @default.
• W2408937128 startingPage "105" @default.
• W2408937128 abstract "To clarify the clinical, cytogenetical and molecular characteristics and prognosis of Ph(+) ALL patients with ABL kinase domain mutations (ABL-KDMs), and to evaluate the therapeutic value of allogeneic hematopoietic stem cell transplantation (allo-HSCT) combined with tyrosine kinase inhibitor (TKI) in these patients.Retrospective analysis of clinical features, molecular genetic characteristics, mutation distribution and prognosis of newly diagnosed Ph(+) ALL patients with ABL-KDMs from February 2010 to August 2014 were performed, and the efficacy of treatment regimen of allo-HSCT combined with different TKIs was compared.Of 88 Ph(+) ALL patients during maintenance treatment stage for ABL-KDMs monitoring, mutation was detected in 42 patients with median time of 8 months from diagnosis to mutation occurrence. The median age of mutation group was 40-year-old, older than that of non-mutation group (32.5-year-old) (P=0.023). The incidence of complex chromosome abnormality of mutation group was higher than that of non-mutation group (P=0.043), with alternations in chromosome 7, 5 and +Ph more frequently observed. There were 21 types of mutation at 18 locations detected, with T315I mutation ranking the top followed by E255K/V, Y253H/F and E459K. Mutation group featured no significant difference in complete remission (CR) rate in contrast to nonmutation group, but was remarkably lower in major molecular remission (MMR) rate than non-mutation group. The 2 year and 5 year overall survival rate of mutation group was 45.4% and 35.0% respectively, much shorter than that of non-mutation group (67.8% and 63.3%), (P=0.047). The median survival of patients with T315I and E255K/V was 19 and 10 months, significantly shorter than that of patients with other mutations. Among the 42 patients with mutations, 14 underwent allo-HSCT, and the median survival was 29 months, longer than that of patients received chemotherapy alone (17 months) (P=0.024). Fourteen allo-HSCT patients were given nilotinib or dasatinib at the time of mutation occurrence, and there was no significant difference in the overall survival in contrast to patients who continue to take imatinib.ABL kinase domain mutations are closely related to the older age and high genomic instability in the newly diagnosed Ph(+) ALL patients. Mutation types showed diversity and complexity, which remarkably affected patients' prognosis and survival. T315I and E255K mutations account for more than half of all cases, characterized by a less favorable prognosis. Currently, allo-HSCT is the only method that has the potential of elongating life expectancy, but the utility of second-generation TKI during relapse does not necessarily have an edge on survival over imatinib." @default.
• W2408937128 created "2016-06-24" @default.
• W2408937128 creator A5006739024 @default.
• W2408937128 creator A5008441442 @default.
• W2408937128 creator A5016325305 @default.
• W2408937128 creator A5022501218 @default.
• W2408937128 creator A5028474331 @default.
• W2408937128 creator A5031641778 @default.
• W2408937128 creator A5048826252 @default.
• W2408937128 creator A5071443000 @default.
• W2408937128 date "2016-02-01" @default.
• W2408937128 modified "2023-09-22" @default.
• W2408937128 title "[Clinical and laboratory characteristics and treatment option for Philadelphia positive acute lymphoblastic leukemia patients with ABL kinase domain mutations]." @default.
• W2408937128 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2016.02.004" @default.
• W2408937128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7348204" @default.
• W2408937128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27014978" @default.
• W2408937128 hasPublicationYear "2016" @default.
• W2408937128 type Work @default.
• W2408937128 sameAs 2408937128 @default.
• W2408937128 citedByCount "0" @default.
• W2408937128 crossrefType "journal-article" @default.
• W2408937128 hasAuthorship W2408937128A5006739024 @default.
• W2408937128 hasAuthorship W2408937128A5008441442 @default.
• W2408937128 hasAuthorship W2408937128A5016325305 @default.
• W2408937128 hasAuthorship W2408937128A5022501218 @default.
• W2408937128 hasAuthorship W2408937128A5028474331 @default.
• W2408937128 hasAuthorship W2408937128A5031641778 @default.
• W2408937128 hasAuthorship W2408937128A5048826252 @default.
• W2408937128 hasAuthorship W2408937128A5071443000 @default.
• W2408937128 hasConcept C104317684 @default.
• W2408937128 hasConcept C121608353 @default.
• W2408937128 hasConcept C125418893 @default.
• W2408937128 hasConcept C126322002 @default.
• W2408937128 hasConcept C138626823 @default.
• W2408937128 hasConcept C143998085 @default.
• W2408937128 hasConcept C163565370 @default.
• W2408937128 hasConcept C170493617 @default.
• W2408937128 hasConcept C2777408962 @default.
• W2408937128 hasConcept C2778461978 @default.
• W2408937128 hasConcept C2778820342 @default.
• W2408937128 hasConcept C2778904597 @default.
• W2408937128 hasConcept C2909962599 @default.
• W2408937128 hasConcept C2911091166 @default.
• W2408937128 hasConcept C42362537 @default.
• W2408937128 hasConcept C501734568 @default.
• W2408937128 hasConcept C54355233 @default.
• W2408937128 hasConcept C71924100 @default.
• W2408937128 hasConcept C86803240 @default.
• W2408937128 hasConcept C90924648 @default.
• W2408937128 hasConceptScore W2408937128C104317684 @default.
• W2408937128 hasConceptScore W2408937128C121608353 @default.
• W2408937128 hasConceptScore W2408937128C125418893 @default.
• W2408937128 hasConceptScore W2408937128C126322002 @default.
• W2408937128 hasConceptScore W2408937128C138626823 @default.
• W2408937128 hasConceptScore W2408937128C143998085 @default.
• W2408937128 hasConceptScore W2408937128C163565370 @default.
• W2408937128 hasConceptScore W2408937128C170493617 @default.
• W2408937128 hasConceptScore W2408937128C2777408962 @default.
• W2408937128 hasConceptScore W2408937128C2778461978 @default.
• W2408937128 hasConceptScore W2408937128C2778820342 @default.
• W2408937128 hasConceptScore W2408937128C2778904597 @default.
• W2408937128 hasConceptScore W2408937128C2909962599 @default.
• W2408937128 hasConceptScore W2408937128C2911091166 @default.
• W2408937128 hasConceptScore W2408937128C42362537 @default.
• W2408937128 hasConceptScore W2408937128C501734568 @default.
• W2408937128 hasConceptScore W2408937128C54355233 @default.
• W2408937128 hasConceptScore W2408937128C71924100 @default.
• W2408937128 hasConceptScore W2408937128C86803240 @default.
• W2408937128 hasConceptScore W2408937128C90924648 @default.
• W2408937128 hasIssue "2" @default.
• W2408937128 hasLocation W24089371281 @default.
• W2408937128 hasOpenAccess W2408937128 @default.
• W2408937128 hasPrimaryLocation W24089371281 @default.
• W2408937128 hasRelatedWork W1991532832 @default.
• W2408937128 hasRelatedWork W2124851360 @default.
• W2408937128 hasRelatedWork W2161605543 @default.
• W2408937128 hasRelatedWork W2340739010 @default.
• W2408937128 hasRelatedWork W2403410214 @default.
• W2408937128 hasRelatedWork W2414734517 @default.
• W2408937128 hasRelatedWork W2562055118 @default.
• W2408937128 hasRelatedWork W2576552777 @default.
• W2408937128 hasRelatedWork W2578686835 @default.
• W2408937128 hasRelatedWork W2590753376 @default.
• W2408937128 hasRelatedWork W2758905850 @default.
• W2408937128 hasRelatedWork W2792470925 @default.
• W2408937128 hasRelatedWork W2883409390 @default.
• W2408937128 hasRelatedWork W2902268210 @default.
• W2408937128 hasRelatedWork W2966615377 @default.
• W2408937128 hasRelatedWork W2978221847 @default.
• W2408937128 hasRelatedWork W2999566312 @default.
• W2408937128 hasRelatedWork W3017239986 @default.
• W2408937128 hasRelatedWork W776857879 @default.
• W2408937128 hasRelatedWork W3101708173 @default.
• W2408937128 hasVolume "37" @default.
• W2408937128 isParatext "false" @default.
• W2408937128 isRetracted "false" @default.
• W2408937128 magId "2408937128" @default.
• W2408937128 workType "article" @default.