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- W240895279 abstract "Previous studies with these proximal tubules showed net NMN absorption. Both unidirectional lumen-to-bath (J/sub NMN//sup 1..-->..b/) and bath-to-lumen (J/sub NMN//sup b..-->..1/) fluxes involve entry into cells down electrochemical gradient by carrier-mediated process and transport out of cells against electrochemical gradient, but J/sub NMN//sup 1..-->..b/ exceeds J/sub NMN//sup b..-->..1/. Tetraethylammonium (TEA) does not inhibit NMN transport and is transported by separate system. In present study, choline, with structure closer to TEA than NMN, also had no effect on J/sub NMN//sup 1..-->..b/ or J/sub NMN//sup b..-->..1/. Because transport out of cells at both membranes could involve countertransport of organic cations or H/sup +/-organic cation exchange, the authors examined effects of unlabeled NMN and H/sup +/ gradients on /sup 3/H-labeled NMN fluxes. Unlabeled NMN in bath (50..mu..M) with labeled NMN in lumen (13 ..mu..M) had no effect on J/sub NMN//sup 1..-->..b/. Thus, there was no evidence of organic cation countertransport for NMN> Lumen-to-bath H/sup +/ gradient (lumen pH, 5.0; bath pH, 7.4) had no effect on J/sub NMN/sup b..-->..1/. Thus, there was no evidence for H/sup +/-NMN exchange involved in NMN transport out of cells at luminal membrane. However, bath-to-lumen H/sup +/ gradient (bath pH, 6.0; lumen pH, 7.5) stimulated J/sub NMN//sup 1..-->..b/more » by about 40% and decreased cell water NMN concentration by about 50%, suggesting that H/sup +/-NMN exchange could contribute to NMN transport out of cells at peritubular membrane.« less" @default.
- W240895279 created "2016-06-24" @default.
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- W240895279 date "1986-03-01" @default.
- W240895279 modified "2023-09-24" @default.
- W240895279 title "Effects of choline, unlabeled N/sup 1/-methylnicotinamide (NMN), and H/sup +/ gradients on labeled NMN transport by isolated, perfused snake renal tubules" @default.
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