Matches in SemOpenAlex for { <https://semopenalex.org/work/W2408987926> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2408987926 endingPage "11" @default.
- W2408987926 startingPage "17601" @default.
- W2408987926 abstract "The mechanisms underlying the growth inhibitory effect of Benzyl isothiocyanate (BITC) against breast cancer are still not fully understood. Therefore, we further investigated the mechanism in BITC triggering breast cancer. In the present study, we found that the overexpression of FOXH1 in breast cancers tissues and cells, and FOXH1 significantly promoted cell proliferation, invasion and tumorigenesis in vitro. FOXH1 significantly increased the expression levels of β-catenin, cyclinD1, and c-myc proteins in breast cancer cells. Furthermore, siβ-catenin reduced FOXH1 promotion of cell proliferation and invasion in breast cancer cells. Taken together, these results suggest that FOXH1 promoted breast cancer cell growth and invasion by potentiating the Wnt/β-catenin pathway, suggesting that FOXH1 may be a potential molecular target for breast cancer prevention and therapy. Furthermore, BITC treatment has remarkable effect on the expression level of FOXH1 and β-catenin mRNA and protein in MCF-7 cells, MDA-MB-231 cells and SUM 159 cells. BITC treatment has an obvious significance on transcriptional activity of FOXH1. Cell growth and invasion inhibition resulting from BITC exposure were significantly augmented by FoxH1 knockdown. In conclusion, the present study provides novel insights into the molecular circuitry of BITC-induced cell death involving FoxH1-mediated tumorigenesis. Thus, the present study provides a novel insight into the underlying mechanism of tumorigenesis in BITC triggering breast cancer, indicating the therapeutic potential of FOXH1 in the treatment of breast cancer." @default.
- W2408987926 created "2016-06-24" @default.
- W2408987926 creator A5001877165 @default.
- W2408987926 creator A5011711230 @default.
- W2408987926 creator A5027639672 @default.
- W2408987926 creator A5036040817 @default.
- W2408987926 date "2015-01-01" @default.
- W2408987926 modified "2023-09-26" @default.
- W2408987926 title "Benzyl isothiocyanate inhibits breast cancer cell tumorigenesis via repression of the FoxH1-Mediated Wnt/β-catenin pathway." @default.
- W2408987926 cites W1529040986 @default.
- W2408987926 cites W1531964529 @default.
- W2408987926 cites W1688070959 @default.
- W2408987926 cites W1949797027 @default.
- W2408987926 cites W1992127683 @default.
- W2408987926 cites W1997008264 @default.
- W2408987926 cites W2006743934 @default.
- W2408987926 cites W2018965952 @default.
- W2408987926 cites W2037795068 @default.
- W2408987926 cites W2041166774 @default.
- W2408987926 cites W2048015102 @default.
- W2408987926 cites W2072111013 @default.
- W2408987926 cites W2088930421 @default.
- W2408987926 cites W2098739118 @default.
- W2408987926 cites W2102840492 @default.
- W2408987926 cites W2122018770 @default.
- W2408987926 cites W2130444978 @default.
- W2408987926 cites W2134542413 @default.
- W2408987926 cites W2146657751 @default.
- W2408987926 cites W2158021558 @default.
- W2408987926 cites W2160298012 @default.
- W2408987926 cites W2161551303 @default.
- W2408987926 cites W2507457907 @default.
- W2408987926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4694250" @default.
- W2408987926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26770350" @default.
- W2408987926 hasPublicationYear "2015" @default.
- W2408987926 type Work @default.
- W2408987926 sameAs 2408987926 @default.
- W2408987926 citedByCount "7" @default.
- W2408987926 countsByYear W24089879262019 @default.
- W2408987926 countsByYear W24089879262020 @default.
- W2408987926 countsByYear W24089879262021 @default.
- W2408987926 countsByYear W24089879262022 @default.
- W2408987926 countsByYear W24089879262023 @default.
- W2408987926 crossrefType "journal-article" @default.
- W2408987926 hasAuthorship W2408987926A5001877165 @default.
- W2408987926 hasAuthorship W2408987926A5011711230 @default.
- W2408987926 hasAuthorship W2408987926A5027639672 @default.
- W2408987926 hasAuthorship W2408987926A5036040817 @default.
- W2408987926 hasConcept C121608353 @default.
- W2408987926 hasConcept C126322002 @default.
- W2408987926 hasConcept C137620995 @default.
- W2408987926 hasConcept C2776572452 @default.
- W2408987926 hasConcept C2779886097 @default.
- W2408987926 hasConcept C502942594 @default.
- W2408987926 hasConcept C530470458 @default.
- W2408987926 hasConcept C55493867 @default.
- W2408987926 hasConcept C555283112 @default.
- W2408987926 hasConcept C62112901 @default.
- W2408987926 hasConcept C62478195 @default.
- W2408987926 hasConcept C71924100 @default.
- W2408987926 hasConcept C86803240 @default.
- W2408987926 hasConcept C95444343 @default.
- W2408987926 hasConceptScore W2408987926C121608353 @default.
- W2408987926 hasConceptScore W2408987926C126322002 @default.
- W2408987926 hasConceptScore W2408987926C137620995 @default.
- W2408987926 hasConceptScore W2408987926C2776572452 @default.
- W2408987926 hasConceptScore W2408987926C2779886097 @default.
- W2408987926 hasConceptScore W2408987926C502942594 @default.
- W2408987926 hasConceptScore W2408987926C530470458 @default.
- W2408987926 hasConceptScore W2408987926C55493867 @default.
- W2408987926 hasConceptScore W2408987926C555283112 @default.
- W2408987926 hasConceptScore W2408987926C62112901 @default.
- W2408987926 hasConceptScore W2408987926C62478195 @default.
- W2408987926 hasConceptScore W2408987926C71924100 @default.
- W2408987926 hasConceptScore W2408987926C86803240 @default.
- W2408987926 hasConceptScore W2408987926C95444343 @default.
- W2408987926 hasIssue "10" @default.
- W2408987926 hasLocation W24089879261 @default.
- W2408987926 hasOpenAccess W2408987926 @default.
- W2408987926 hasPrimaryLocation W24089879261 @default.
- W2408987926 hasRelatedWork W2032430075 @default.
- W2408987926 hasRelatedWork W2136426251 @default.
- W2408987926 hasRelatedWork W2262045065 @default.
- W2408987926 hasRelatedWork W2415905581 @default.
- W2408987926 hasRelatedWork W2529394556 @default.
- W2408987926 hasRelatedWork W2758523885 @default.
- W2408987926 hasRelatedWork W2782224317 @default.
- W2408987926 hasRelatedWork W2783287126 @default.
- W2408987926 hasRelatedWork W2965391674 @default.
- W2408987926 hasRelatedWork W1804075262 @default.
- W2408987926 hasVolume "8" @default.
- W2408987926 isParatext "false" @default.
- W2408987926 isRetracted "false" @default.
- W2408987926 magId "2408987926" @default.
- W2408987926 workType "article" @default.