Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409016352> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2409016352 endingPage "9" @default.
- W2409016352 startingPage "2564" @default.
- W2409016352 abstract "to investigate the expression and location of caveolin-1 (Cav-1), aquaporin 1 (AQP1) and AQP5 in the lung of acute pancreatitis-associated lung injury rats and to determine the role of these molecules in the pathologic progress and the potential therapeutic mechanisms of Qingyitang.forty Wistar rats were randomly divided into sham operation (SHAM) group, acute lung injury (ALI) group, dexamethasone (DEX) group and Qingyitang (QYT) group. ALI was induced by reverse injection of deoxycholate into biliopancreatic duct of rats. Blood and lung tissues were collected after 24 h. Serum amylase, lung wet/dry (W/D) ratio and pathological section were detected to evaluate the degree of lung injury. reverse transcription-polymerase chain reaction was taken to detect the mRNA levels of Cav-1, AQP1 and AQP5. Lipid rafts were prepared for detection of the distribution and expression level of Cav-1, AQP1 and AQP5 proteins by Western blot.the concentration of serum amylase, the value of W/D and the degree of pathological lung injury obviously increased in ALI rats. Cav-1, AQP1 and AQP5 were present in the lung while the mRNA level decreased in ALI rats. Cav-1 appeared mainly in lipid rafts and less in non-lipid rafts. AQP1 was localized to lipid rafts while AQP5 to non-lipid rafts. The localization of these three molecules in the lung of ALI rats did not change compared with SHAM rats while their protein levels decreased. Compared with ALI rats, the concentration of serum amylase, the value of W/D and the degree of pathological lung injury obviously decreased in DEX and QYT rats. The mRNA and the protein expression of Cav-1, AQP1 and AQP5 increased in various degrees by DEX or QYT treatment.Cav-1 and AQP1 are enriched in lipid rafts while AQP5 in non-lipid rafts. The down-regulated expression of these three molecules may play important role in acute pancreatitis-associated lung injury. DEX and QYT may relieve lung injury effectively by up-regulating the expressions of Cav-1, AQP1 and AQP5." @default.
- W2409016352 created "2016-06-24" @default.
- W2409016352 creator A5020266322 @default.
- W2409016352 creator A5039944796 @default.
- W2409016352 creator A5043941187 @default.
- W2409016352 creator A5052883326 @default.
- W2409016352 creator A5061333926 @default.
- W2409016352 date "2010-09-28" @default.
- W2409016352 modified "2023-09-23" @default.
- W2409016352 title "[Expression of Cav-1, AQP1 and AQP5 in lung of acute pancreatitis-associated lung injury rats and the therapeutic role of Qingyitang]." @default.
- W2409016352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21092464" @default.
- W2409016352 hasPublicationYear "2010" @default.
- W2409016352 type Work @default.
- W2409016352 sameAs 2409016352 @default.
- W2409016352 citedByCount "2" @default.
- W2409016352 countsByYear W24090163522015 @default.
- W2409016352 countsByYear W24090163522020 @default.
- W2409016352 crossrefType "journal-article" @default.
- W2409016352 hasAuthorship W2409016352A5020266322 @default.
- W2409016352 hasAuthorship W2409016352A5039944796 @default.
- W2409016352 hasAuthorship W2409016352A5043941187 @default.
- W2409016352 hasAuthorship W2409016352A5052883326 @default.
- W2409016352 hasAuthorship W2409016352A5061333926 @default.
- W2409016352 hasConcept C104317684 @default.
- W2409016352 hasConcept C126322002 @default.
- W2409016352 hasConcept C127413603 @default.
- W2409016352 hasConcept C134018914 @default.
- W2409016352 hasConcept C142724271 @default.
- W2409016352 hasConcept C177586851 @default.
- W2409016352 hasConcept C185592680 @default.
- W2409016352 hasConcept C201289731 @default.
- W2409016352 hasConcept C2775845273 @default.
- W2409016352 hasConcept C2775967933 @default.
- W2409016352 hasConcept C2776415932 @default.
- W2409016352 hasConcept C2776670229 @default.
- W2409016352 hasConcept C2777714996 @default.
- W2409016352 hasConcept C2778163477 @default.
- W2409016352 hasConcept C2780401358 @default.
- W2409016352 hasConcept C55493867 @default.
- W2409016352 hasConcept C71924100 @default.
- W2409016352 hasConcept C78519656 @default.
- W2409016352 hasConcept C79266657 @default.
- W2409016352 hasConceptScore W2409016352C104317684 @default.
- W2409016352 hasConceptScore W2409016352C126322002 @default.
- W2409016352 hasConceptScore W2409016352C127413603 @default.
- W2409016352 hasConceptScore W2409016352C134018914 @default.
- W2409016352 hasConceptScore W2409016352C142724271 @default.
- W2409016352 hasConceptScore W2409016352C177586851 @default.
- W2409016352 hasConceptScore W2409016352C185592680 @default.
- W2409016352 hasConceptScore W2409016352C201289731 @default.
- W2409016352 hasConceptScore W2409016352C2775845273 @default.
- W2409016352 hasConceptScore W2409016352C2775967933 @default.
- W2409016352 hasConceptScore W2409016352C2776415932 @default.
- W2409016352 hasConceptScore W2409016352C2776670229 @default.
- W2409016352 hasConceptScore W2409016352C2777714996 @default.
- W2409016352 hasConceptScore W2409016352C2778163477 @default.
- W2409016352 hasConceptScore W2409016352C2780401358 @default.
- W2409016352 hasConceptScore W2409016352C55493867 @default.
- W2409016352 hasConceptScore W2409016352C71924100 @default.
- W2409016352 hasConceptScore W2409016352C78519656 @default.
- W2409016352 hasConceptScore W2409016352C79266657 @default.
- W2409016352 hasIssue "36" @default.
- W2409016352 hasLocation W24090163521 @default.
- W2409016352 hasOpenAccess W2409016352 @default.
- W2409016352 hasPrimaryLocation W24090163521 @default.
- W2409016352 hasRelatedWork W1995245298 @default.
- W2409016352 hasRelatedWork W2042996328 @default.
- W2409016352 hasRelatedWork W2142098455 @default.
- W2409016352 hasRelatedWork W2317177510 @default.
- W2409016352 hasRelatedWork W234906731 @default.
- W2409016352 hasRelatedWork W2397113604 @default.
- W2409016352 hasRelatedWork W2465839395 @default.
- W2409016352 hasRelatedWork W2563328145 @default.
- W2409016352 hasRelatedWork W2565819700 @default.
- W2409016352 hasRelatedWork W2603971999 @default.
- W2409016352 hasRelatedWork W2732617723 @default.
- W2409016352 hasRelatedWork W2788765227 @default.
- W2409016352 hasRelatedWork W2891372418 @default.
- W2409016352 hasRelatedWork W2912814500 @default.
- W2409016352 hasRelatedWork W2922755946 @default.
- W2409016352 hasRelatedWork W2969180417 @default.
- W2409016352 hasRelatedWork W2969788841 @default.
- W2409016352 hasRelatedWork W2986833515 @default.
- W2409016352 hasRelatedWork W3121141334 @default.
- W2409016352 hasRelatedWork W3173674015 @default.
- W2409016352 hasVolume "90" @default.
- W2409016352 isParatext "false" @default.
- W2409016352 isRetracted "false" @default.
- W2409016352 magId "2409016352" @default.
- W2409016352 workType "article" @default.