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- W2409038109 abstract "Detailed studies of immune reactivity were performed in 154 patients with primary lung cancer, 20 patients with benign thoracic lesions, and 109 healthy persons. Reactions to the 2,4-dinitrochlorobenzene (DNCB) skin test were positive in 73 per cent of patients with lung cancer and all (100 per cent) of the patients with benign disease (p < 0.05). The incidence of DNCB reactions was 78 per cent for Stage I and II cancers (37 patients), 73 per cent for resectable Stage III cancer (22 patients), and 66 per cent in patients with unresectable or inoperable Stage III cancer. DNCB reactivity showed a relationship to primary histology. The incidence of DNCB positive reactions was 80 per cent in patients with epidermoid carcinoma versus 57 per cent in patients with adenocarcinoma, 64 per cent in patients with oat cell cancer, and 80 per cent in patients with terminal bronchiolar carcinoma. In vitro immune studies correlated best with stage of disease. These included the absolute lymphocyte count and absolute T cell count and lymphocyte stimulation with mitogens phytohemagglutinin (PHA), pokeweed mitogen (PWM), and conconavalen A (Con A). These values were in the normal range in patients with Stage I cancer but were significantly depressed in patients with Stage III cancer. Survival curves were plotted in patients with Stage III disease according to the responses to three immune parameters: DNCB, absolute lymphocyte count, and PHA stimulation. Although patients with normal reactions generally had better survival rates, PHA responses showed the most significant correlation to survival. These tests support the usefulness of immune testing as an additional parameter of assessing biological risk in patients with primary lung cancer." @default.
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- W2409038109 date "1976-09-01" @default.
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- W2409038109 title "Immune reactivity in primary carcinoma of the lung and its relation to prognosis" @default.
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- W2409038109 doi "https://doi.org/10.1016/s0022-5223(19)40060-3" @default.
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