FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409069927> ?p ?o ?g. }

• W2409069927 abstract "Chronic Myeloid leukemia (CML) is a disorder causing uncontrolled growth of myeloproliferative blast cells. Tyrosine kinase inhibitors are not really useful in advanced stages and have their own side effects, reactions and resistance as well. Till date, CML can be fully cured only by bone marrow transplantation (BMT) which has its own limitations and thus need further studies to increase better survival of CML patients by this procedure. Our lab at Jaslok Hospital has been working on studying and characterizing mesenchymal stem cells in various types of hematological malignancies. We came up with a concept of isolating and characterizing mesenchymal stem cells (MSCs) from peripheral blood of a CML patient which can be used in combination with Bone Marrow Transplantation in the same CML patient. Our study has shown that the stem cells derived from peripheral blood of CML patient were found to be BCR/ABL -ve . We designated this cell line as a “BCR/ABL -ve ” cell line. Molecular characterization of these cells further confirmed their Mesenchymal phenotypes with distinct expression of CD105, CD13 and CD73 genes. Interestingly these cells also expressed pluripotency genes such as OCT4 and NANOG and cytokines i.e. IL6 and TNFα. We further confirmed the normal phenotype of BCR/ABL -ve MSCs by localizing expression of H-Ras, Rb, P53, P16, P21, and EGFR and Ki67 cancer related proteins in these cells by immunofluorescence Microscopy and by in vitro transformation assay. Thus, we suggest that these normal BCR/ABL -ve MSCs derived from CML patient’s peripheral blood can be used in addition to BMT procedure for a better recovery of CML disease in near future." @default.
• W2409069927 created "2016-06-24" @default.
• W2409069927 creator A5040863713 @default.
• W2409069927 creator A5057826681 @default.
• W2409069927 date "2015-01-01" @default.
• W2409069927 modified "2023-09-26" @default.
• W2409069927 title "Isolation, Characterization and Application of BCR-ABL-ve Mesenchymal Stem Cells Derived from Peripheral Blood of Chronic Myeloid Leukemia (CML) in Enhancing Potentiality of Bone Marrow Transplantation in CML Patients" @default.
• W2409069927 cites W1274344746 @default.
• W2409069927 cites W1974766733 @default.
• W2409069927 cites W1978851576 @default.
• W2409069927 cites W1997562197 @default.
• W2409069927 cites W1998593414 @default.
• W2409069927 cites W2004267703 @default.
• W2409069927 cites W2006917576 @default.
• W2409069927 cites W2023325374 @default.
• W2409069927 cites W2030435804 @default.
• W2409069927 cites W2030583421 @default.
• W2409069927 cites W2037837200 @default.
• W2409069927 cites W2038664912 @default.
• W2409069927 cites W2046972939 @default.
• W2409069927 cites W2048993178 @default.
• W2409069927 cites W2050642909 @default.
• W2409069927 cites W2054251966 @default.
• W2409069927 cites W2083086726 @default.
• W2409069927 cites W2083353096 @default.
• W2409069927 cites W2096882254 @default.
• W2409069927 cites W2107367449 @default.
• W2409069927 cites W2109694699 @default.
• W2409069927 cites W2135470097 @default.
• W2409069927 cites W2142950614 @default.
• W2409069927 cites W2148743957 @default.
• W2409069927 cites W2329648702 @default.
• W2409069927 cites W2386721483 @default.
• W2409069927 cites W2412827858 @default.
• W2409069927 cites W2418510010 @default.
• W2409069927 cites W253245484 @default.
• W2409069927 cites W2600977930 @default.
• W2409069927 cites W2153426735 @default.
• W2409069927 doi "https://doi.org/10.16966/2472-6990.101" @default.
• W2409069927 hasPublicationYear "2015" @default.
• W2409069927 type Work @default.
• W2409069927 sameAs 2409069927 @default.
• W2409069927 citedByCount "0" @default.
• W2409069927 crossrefType "journal-article" @default.
• W2409069927 hasAuthorship W2409069927A5040863713 @default.
• W2409069927 hasAuthorship W2409069927A5057826681 @default.
• W2409069927 hasBestOaLocation W24090699271 @default.
• W2409069927 hasConcept C126322002 @default.
• W2409069927 hasConcept C142724271 @default.
• W2409069927 hasConcept C198826908 @default.
• W2409069927 hasConcept C203014093 @default.
• W2409069927 hasConcept C2778729363 @default.
• W2409069927 hasConcept C2780007613 @default.
• W2409069927 hasConcept C28328180 @default.
• W2409069927 hasConcept C2911091166 @default.
• W2409069927 hasConcept C502942594 @default.
• W2409069927 hasConcept C71924100 @default.
• W2409069927 hasConcept C86803240 @default.
• W2409069927 hasConcept C95444343 @default.
• W2409069927 hasConceptScore W2409069927C126322002 @default.
• W2409069927 hasConceptScore W2409069927C142724271 @default.
• W2409069927 hasConceptScore W2409069927C198826908 @default.
• W2409069927 hasConceptScore W2409069927C203014093 @default.
• W2409069927 hasConceptScore W2409069927C2778729363 @default.
• W2409069927 hasConceptScore W2409069927C2780007613 @default.
• W2409069927 hasConceptScore W2409069927C28328180 @default.
• W2409069927 hasConceptScore W2409069927C2911091166 @default.
• W2409069927 hasConceptScore W2409069927C502942594 @default.
• W2409069927 hasConceptScore W2409069927C71924100 @default.
• W2409069927 hasConceptScore W2409069927C86803240 @default.
• W2409069927 hasConceptScore W2409069927C95444343 @default.
• W2409069927 hasLocation W24090699271 @default.
• W2409069927 hasOpenAccess W2409069927 @default.
• W2409069927 hasPrimaryLocation W24090699271 @default.
• W2409069927 hasRelatedWork W1812137864 @default.
• W2409069927 hasRelatedWork W1938140712 @default.
• W2409069927 hasRelatedWork W1965619359 @default.
• W2409069927 hasRelatedWork W1967097483 @default.
• W2409069927 hasRelatedWork W1992382947 @default.
• W2409069927 hasRelatedWork W1994797642 @default.
• W2409069927 hasRelatedWork W2045175809 @default.
• W2409069927 hasRelatedWork W2078555565 @default.
• W2409069927 hasRelatedWork W2394168074 @default.
• W2409069927 hasRelatedWork W2399822832 @default.
• W2409069927 hasRelatedWork W2557751752 @default.
• W2409069927 hasRelatedWork W2559198077 @default.
• W2409069927 hasRelatedWork W2578249300 @default.
• W2409069927 hasRelatedWork W2590914352 @default.
• W2409069927 hasRelatedWork W2607359156 @default.
• W2409069927 hasRelatedWork W2607524091 @default.
• W2409069927 hasRelatedWork W2955039457 @default.
• W2409069927 hasRelatedWork W2981090231 @default.
• W2409069927 hasRelatedWork W302802858 @default.
• W2409069927 hasRelatedWork W3180721253 @default.
• W2409069927 isParatext "false" @default.
• W2409069927 isRetracted "false" @default.
• W2409069927 magId "2409069927" @default.
• W2409069927 workType "article" @default.