Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409146763> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2409146763 endingPage "27" @default.
- W2409146763 startingPage "14" @default.
- W2409146763 abstract "The pathophysiology of the syndrome of congestive heart failure (CHF) is different in elderly patients compared to middle-aged subjects. When the syndrome of CHF predominantly results from left ventricular (LV) systolic dysfunction, peripheral mechanisms in elderly patients are less apt to compensate for the decline in LV performance due to deconditioning of the skeletal muscles, decreased vasodilatory response to exercise, and reduced capacity to excrete sodium. These all develop with age. LV diastolic dysfunction, i.e., LV filling impairment, appears to be a more frequent cause of CHF in elderly patients than in middle-aged subjects. Hypertrophy of the cardiac myocyte is associated with a prolongation of the calcium transient which, in turn, results from a decreased concentration of the enzyme responsible for reuptake of calcium in the sarcoplasmic reticulum. Cardiac myocyte hypertrophy results from a steady loss of myocytes and a progressive rise in arterial impedance which are both observed with aging. Notwithstanding subendocardial myocardial ischemia which is frequently associated with LV wall hypertrophy, prolongation of the calcium transient leads to impaired LV wall relaxation and the syndrome of LV diastolic dysfunction. The goals of therapy are also different in elderly patients compared to middle-aged patients. In elderly patients, one is less concerned about restoring a near normal exercise capacity, and aims at preventing acute episodes of decompensation which frequently accompany excessive sodium intake. Therefore, strict adherence to diet and careful titration of the dosages of medication to renal function are important considerations when treating CHF in elderly patients. In particular, cardiac glycosides, which should be avoided with CHF due to LV diastolic dysfunction, should be carefully titrated to creatinine clearance and body weight when treating elderly patients with LV systolic dysfunction in sinus rhythm. Similarly, the dosages of most angiotensin-converting enzyme inhibitors should be reduced in elderly patients." @default.
- W2409146763 created "2016-06-24" @default.
- W2409146763 creator A5007024746 @default.
- W2409146763 creator A5008316114 @default.
- W2409146763 creator A5084406312 @default.
- W2409146763 date "1993-01-01" @default.
- W2409146763 modified "2023-09-23" @default.
- W2409146763 title "From Left Ventricular Dysfunction to Heart Failure in the Elderly Patient." @default.
- W2409146763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11416281" @default.
- W2409146763 hasPublicationYear "1993" @default.
- W2409146763 type Work @default.
- W2409146763 sameAs 2409146763 @default.
- W2409146763 citedByCount "2" @default.
- W2409146763 crossrefType "journal-article" @default.
- W2409146763 hasAuthorship W2409146763A5007024746 @default.
- W2409146763 hasAuthorship W2409146763A5008316114 @default.
- W2409146763 hasAuthorship W2409146763A5084406312 @default.
- W2409146763 hasConcept C126322002 @default.
- W2409146763 hasConcept C164705383 @default.
- W2409146763 hasConcept C167414201 @default.
- W2409146763 hasConcept C2776002628 @default.
- W2409146763 hasConcept C2778198053 @default.
- W2409146763 hasConcept C57900726 @default.
- W2409146763 hasConcept C71924100 @default.
- W2409146763 hasConcept C84393581 @default.
- W2409146763 hasConceptScore W2409146763C126322002 @default.
- W2409146763 hasConceptScore W2409146763C164705383 @default.
- W2409146763 hasConceptScore W2409146763C167414201 @default.
- W2409146763 hasConceptScore W2409146763C2776002628 @default.
- W2409146763 hasConceptScore W2409146763C2778198053 @default.
- W2409146763 hasConceptScore W2409146763C57900726 @default.
- W2409146763 hasConceptScore W2409146763C71924100 @default.
- W2409146763 hasConceptScore W2409146763C84393581 @default.
- W2409146763 hasIssue "1" @default.
- W2409146763 hasLocation W24091467631 @default.
- W2409146763 hasOpenAccess W2409146763 @default.
- W2409146763 hasPrimaryLocation W24091467631 @default.
- W2409146763 hasRelatedWork W1989096941 @default.
- W2409146763 hasRelatedWork W2032899245 @default.
- W2409146763 hasRelatedWork W2061213214 @default.
- W2409146763 hasRelatedWork W2104697450 @default.
- W2409146763 hasRelatedWork W2125028265 @default.
- W2409146763 hasRelatedWork W2174461107 @default.
- W2409146763 hasRelatedWork W2323021256 @default.
- W2409146763 hasRelatedWork W2337739010 @default.
- W2409146763 hasRelatedWork W2922135971 @default.
- W2409146763 hasRelatedWork W2185835103 @default.
- W2409146763 hasVolume "2" @default.
- W2409146763 isParatext "false" @default.
- W2409146763 isRetracted "false" @default.
- W2409146763 magId "2409146763" @default.
- W2409146763 workType "article" @default.