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• W2409155655 abstract "Ricin induced the release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta by human peripheral-blood mononuclear cells in a dose- and time-dependent manner. The inhibition induced by ricin upon the phytohaemagglutinin (PHA)-driven lymphocyte proliferation was greater in cultures of mononuclear cells than that observed in monocyte-free cultures of lymphocytes, and was decreased after addition of an anti-TNF-alpha antibody to PHA-activated cultures. Low levels of TNF-alpha were detected in plasma from rats poisoned with ricin. These results suggest that ricin induced the release of macrophage-derived cytokines which may have a role in the pathogenesis of ricin toxic effects." @default.
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• W2409155655 date "1993-09-01" @default.
• W2409155655 modified "2023-09-23" @default.
• W2409155655 title "Ricin induces the production of tumour necrosis factor-<i>α</i> and interleukin-1 <i>β</i> by human peripheral-blood mononuclear cells" @default.
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• W2409155655 doi "https://doi.org/10.1042/bj2940517" @default.
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