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- W2409171504 startingPage "C382" @default.
- W2409171504 abstract "The weak base acridine orange (AO) has been shown to be accumulated by the insulin-containing secretory granules of cultured beta-cells in response to high glucose. Various lines of evidence indicate that this accumulation is due to a pH gradient. Thus ionophores such as monensin and nigericin abolish the glucose-induced accumulation, and a high concentration of the weak base, benzylamine, results in swelling of the granules. In the absence of glucose, ATP addition to digitonin-permeabilized cells also results in dye uptake. These data also suggest that a primary or secondary active accumulation mechanism for hydrogen ions exists across the granule membrane." @default.
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- W2409171504 date "1982-05-01" @default.
- W2409171504 modified "2023-10-18" @default.
- W2409171504 title "Glucose-induced proton uptake in secretory granules of beta-cells in monolayer culture" @default.
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- W2409171504 doi "https://doi.org/10.1152/ajpcell.1982.242.5.c382" @default.
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