FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409209783> ?p ?o ?g. }

• W2409209783 endingPage "18" @default.
• W2409209783 startingPage "10" @default.
• W2409209783 abstract "13C-Metabolic flux analysis (13C-MFA) is a widely used approach in metabolic engineering for quantifying intracellular metabolic fluxes. The precision of fluxes determined by 13C-MFA depends largely on the choice of isotopic tracers and the specific set of labeling measurements. A recent advance in the field is the use of parallel labeling experiments for improved flux precision and accuracy. However, as of today, no systemic methods exist for identifying optimal tracers for parallel labeling experiments. In this contribution, we have addressed this problem by introducing a new scoring system and evaluating thousands of different isotopic tracer schemes. Based on this extensive analysis we have identified optimal tracers for 13C-MFA. The best single tracers were doubly 13C-labeled glucose tracers, including [1,6-13C]glucose, [5,6-13C]glucose and [1,2-13C]glucose, which consistently produced the highest flux precision independent of the metabolic flux map (here, 100 random flux maps were evaluated). Moreover, we demonstrate that pure glucose tracers perform better overall than mixtures of glucose tracers. For parallel labeling experiments the optimal isotopic tracers were [1,6-13C]glucose and [1,2-13C]glucose. Combined analysis of [1,6-13C]glucose and [1,2-13C]glucose labeling data improved the flux precision score by nearly 20-fold compared to widely use tracer mixture 80% [1-13C]glucose +20% [U-13C]glucose." @default.
• W2409209783 created "2016-06-24" @default.
• W2409209783 creator A5032966193 @default.
• W2409209783 creator A5060360737 @default.
• W2409209783 creator A5066686608 @default.
• W2409209783 date "2016-11-01" @default.
• W2409209783 modified "2023-09-25" @default.
• W2409209783 title "Optimal tracers for parallel labeling experiments and 13C metabolic flux analysis: A new precision and synergy scoring system" @default.
• W2409209783 cites W1781745633 @default.
• W2409209783 cites W1968600644 @default.
• W2409209783 cites W1968803553 @default.
• W2409209783 cites W1975931269 @default.
• W2409209783 cites W1976552586 @default.
• W2409209783 cites W1981299471 @default.
• W2409209783 cites W1986705073 @default.
• W2409209783 cites W1999612141 @default.
• W2409209783 cites W2003169371 @default.
• W2409209783 cites W2008421457 @default.
• W2409209783 cites W2009378698 @default.
• W2409209783 cites W2012583526 @default.
• W2409209783 cites W2013116502 @default.
• W2409209783 cites W2014323212 @default.
• W2409209783 cites W2023617120 @default.
• W2409209783 cites W2023716424 @default.
• W2409209783 cites W2030540851 @default.
• W2409209783 cites W2033471108 @default.
• W2409209783 cites W2039977436 @default.
• W2409209783 cites W2041956479 @default.
• W2409209783 cites W2044354987 @default.
• W2409209783 cites W2048374178 @default.
• W2409209783 cites W2049759143 @default.
• W2409209783 cites W2057073472 @default.
• W2409209783 cites W2067238003 @default.
• W2409209783 cites W2076863223 @default.
• W2409209783 cites W2078814292 @default.
• W2409209783 cites W2083364998 @default.
• W2409209783 cites W2083807792 @default.
• W2409209783 cites W2091282042 @default.
• W2409209783 cites W2092493462 @default.
• W2409209783 cites W2095203814 @default.
• W2409209783 cites W2115080303 @default.
• W2409209783 cites W2118553819 @default.
• W2409209783 cites W2166491123 @default.
• W2409209783 cites W2219205942 @default.
• W2409209783 cites W2238139779 @default.
• W2409209783 cites W2294781959 @default.
• W2409209783 cites W2316274763 @default.
• W2409209783 cites W2318464657 @default.
• W2409209783 cites W2328166881 @default.
• W2409209783 cites W2332922869 @default.
• W2409209783 cites W2401624724 @default.
• W2409209783 cites W2425734855 @default.
• W2409209783 cites W2462095501 @default.
• W2409209783 doi "https://doi.org/10.1016/j.ymben.2016.06.001" @default.
• W2409209783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5891732" @default.
• W2409209783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27267409" @default.
• W2409209783 hasPublicationYear "2016" @default.
• W2409209783 type Work @default.
• W2409209783 sameAs 2409209783 @default.
• W2409209783 citedByCount "65" @default.
• W2409209783 countsByYear W24092097832016 @default.
• W2409209783 countsByYear W24092097832017 @default.
• W2409209783 countsByYear W24092097832018 @default.
• W2409209783 countsByYear W24092097832019 @default.
• W2409209783 countsByYear W24092097832020 @default.
• W2409209783 countsByYear W24092097832021 @default.
• W2409209783 countsByYear W24092097832022 @default.
• W2409209783 countsByYear W24092097832023 @default.
• W2409209783 crossrefType "journal-article" @default.
• W2409209783 hasAuthorship W2409209783A5032966193 @default.
• W2409209783 hasAuthorship W2409209783A5060360737 @default.
• W2409209783 hasAuthorship W2409209783A5066686608 @default.
• W2409209783 hasBestOaLocation W24092097832 @default.
• W2409209783 hasConcept C107872376 @default.
• W2409209783 hasConcept C110872660 @default.
• W2409209783 hasConcept C121332964 @default.
• W2409209783 hasConcept C156398188 @default.
• W2409209783 hasConcept C158787203 @default.
• W2409209783 hasConcept C160941953 @default.
• W2409209783 hasConcept C178790620 @default.
• W2409209783 hasConcept C185059815 @default.
• W2409209783 hasConcept C185544564 @default.
• W2409209783 hasConcept C185592680 @default.
• W2409209783 hasConcept C186060115 @default.
• W2409209783 hasConcept C18903297 @default.
• W2409209783 hasConcept C22117777 @default.
• W2409209783 hasConcept C2778863792 @default.
• W2409209783 hasConcept C2993678126 @default.
• W2409209783 hasConcept C36674120 @default.
• W2409209783 hasConcept C55493867 @default.
• W2409209783 hasConcept C62231903 @default.
• W2409209783 hasConcept C62520636 @default.
• W2409209783 hasConcept C68709404 @default.
• W2409209783 hasConcept C86803240 @default.
• W2409209783 hasConceptScore W2409209783C107872376 @default.
• W2409209783 hasConceptScore W2409209783C110872660 @default.
• W2409209783 hasConceptScore W2409209783C121332964 @default.
• W2409209783 hasConceptScore W2409209783C156398188 @default.

• next