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- W2409217205 abstract "The binding of small molecules to non-canonical nucleic acid structures has been a major focus of rational drug design. Among the non-canonical nucleic acid structures, targeting poly(A) using small molecules has attracted a special interest due to the cellular functions of poly(A) tails. Here, the methods for determining the binding of a small molecule to poly(A) using UV-visible(UV-Vis) and Circular Dichroism (CD) Spectroscopy are described. Experiments used in determining the melting temperature, binding stoichiometry and dissociation constant of poly(A)-small molecule systems are depicted." @default.
- W2409217205 created "2016-06-24" @default.
- W2409217205 creator A5019043648 @default.
- W2409217205 date "2014-01-01" @default.
- W2409217205 modified "2023-09-25" @default.
- W2409217205 title "Small Molecule Recognition of Poly(A)" @default.
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- W2409217205 doi "https://doi.org/10.1007/978-1-62703-971-0_8" @default.
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