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• W2409309219 endingPage "1143" @default.
• W2409309219 startingPage "1141" @default.
• W2409309219 abstract "Abstract We studied the action of alpha-interferon (IFN) and interleukin-2 (IL- 2) on natural killer (NK)-rich fractions and autologous tumor cells from two patients with hairy cell leukemia (HCL). The addition of IFN or IL-2 to the NK-rich fractions resulted in a significant increase in NK activity against the autologous tumor cells. This stimulatory effect was blocked if the target hairy cells (HCs) were preincubated with either IFN or IL-2. Pretreatment of the HCs with anti-Tac antibody entirely prevented the blocking effect of IL-2 and partially the blocking effect of IFN. One patient was treated with recombinant alpha c-IFN. After 2 months there was a dramatic reduction in the number of HCs in the peripheral blood coincident with the loss of the protection effect of IFN against NK lysis of the patient's HCs. NK activity against autologous tumor cells correlated poorly with that against the K562 cell line. We conclude that there is a discordant effect of IFN and IL-2 on NK activity and HC sensitivity to lysis. The Tac receptor appears to play a role in this sensitivity. Caution should be exercised in extrapolating the effects of NK activity against K562 cells to those on HC targets." @default.
• W2409309219 created "2016-06-24" @default.
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• W2409309219 date "1988-04-01" @default.
• W2409309219 modified "2023-09-27" @default.
• W2409309219 title "Discordant effect of interferon on natural killer activity and tumor cell sensitivity to lysis in hairy cell leukemia" @default.
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• W2409309219 doi "https://doi.org/10.1182/blood.v71.4.1141.1141" @default.
• W2409309219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3258536" @default.
• W2409309219 hasPublicationYear "1988" @default.
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