FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409321621> ?p ?o ?g. }

• W2409321621 endingPage "120" @default.
• W2409321621 startingPage "113" @default.
• W2409321621 abstract "Vitamin D exerts anti-inflammatory actions both in vitro and in murine models of colitis. In previous studies, we demonstrated that vitamin D protects against the development of colitis by maintaining the integrity of the intestinal mucosal barrier.We sought to evaluate whether deficient serum 25 hydroxyvitamin D [25(OH)D] concentrations are associated with increased mucosal inflammation, a loss of epithelial junctional proteins, and an increase in mucosal inflammatory cytokines in patients with ulcerative colitis (UC).We prospectively enrolled 230 subjects with UC. Serum 25(OH)D concentrations were compared with the Mayo endoscopic score, the total Mayo score, and histologic activity. Colonic mucosal expression concentrations of vitamin D receptor (VDR), E-cadherin, zonula occluden 1 (ZO-1), occludin, claudin-2, tumor necrosis factor α (TNF-α), and interleukin 8 (IL-8) were compared between dichotomous groups with low or high serum 25(OH)D concentrations.The mean serum 25(OH)D concentration was 21.8 ng/mL. Subjects stratified by concentrations included 12.6% ≥30 ng/mL, 45.6% ≥20 to <30 ng/mL, 37.4% ≥10 to <20 ng/mL, and 4.4% <10 ng/mL. There was an inverse association between serum 25(OH)D concentrations and mucosal inflammation as assessed by the Mayo endoscopy score (P = 0.01), disease activity as indicated by the total Mayo score (P = 0.001), and histologic activity (P = 0.02). A serum 25(OH)D concentration <20 ng/mL was associated with decreased mucosal transcript and protein expression concentrations of VDR, E-cadherin, and occludin as well as decreased protein expression of ZO-1, whereas TNF-α and IL-8 mucosal transcript expression concentrations were increased.In UC patients, serum 25(OH)D concentration is inversely correlated with mucosal inflammation and disease activity. These results, coupled with the findings that serum 25(OH)D concentrations correlate with the mucosal expression of VDR as well as epithelial junction proteins and inversely with proinflammatory cytokines, suggest that vitamin D deficiency may contribute to UC inflammation by disrupting epithelial barrier function." @default.
• W2409321621 created "2016-06-24" @default.
• W2409321621 creator A5002536253 @default.
• W2409321621 creator A5005112247 @default.
• W2409321621 creator A5011739304 @default.
• W2409321621 creator A5023182644 @default.
• W2409321621 creator A5037139777 @default.
• W2409321621 creator A5041496187 @default.
• W2409321621 creator A5046643472 @default.
• W2409321621 creator A5049169459 @default.
• W2409321621 creator A5053082854 @default.
• W2409321621 creator A5056831358 @default.
• W2409321621 creator A5058422906 @default.
• W2409321621 creator A5059142660 @default.
• W2409321621 creator A5063018115 @default.
• W2409321621 creator A5069117498 @default.
• W2409321621 creator A5071025708 @default.
• W2409321621 creator A5071250955 @default.
• W2409321621 creator A5082413734 @default.
• W2409321621 creator A5089137150 @default.
• W2409321621 date "2016-06-08" @default.
• W2409321621 modified "2023-10-17" @default.
• W2409321621 title "Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis" @default.
• W2409321621 cites W1508371220 @default.
• W2409321621 cites W1544124240 @default.
• W2409321621 cites W1861971043 @default.
• W2409321621 cites W1868478050 @default.
• W2409321621 cites W1895343791 @default.
• W2409321621 cites W1915935221 @default.
• W2409321621 cites W1956294817 @default.
• W2409321621 cites W1956824670 @default.
• W2409321621 cites W196146463 @default.
• W2409321621 cites W1970516100 @default.
• W2409321621 cites W1980122293 @default.
• W2409321621 cites W1982622210 @default.
• W2409321621 cites W1987374295 @default.
• W2409321621 cites W1998753682 @default.
• W2409321621 cites W2002357628 @default.
• W2409321621 cites W2016434905 @default.
• W2409321621 cites W2017851530 @default.
• W2409321621 cites W2018038375 @default.
• W2409321621 cites W2032501249 @default.
• W2409321621 cites W2038621270 @default.
• W2409321621 cites W2042578192 @default.
• W2409321621 cites W2047681882 @default.
• W2409321621 cites W2053110177 @default.
• W2409321621 cites W2060253882 @default.
• W2409321621 cites W2075522658 @default.
• W2409321621 cites W2081274686 @default.
• W2409321621 cites W2089340794 @default.
• W2409321621 cites W2093206323 @default.
• W2409321621 cites W2093915139 @default.
• W2409321621 cites W2107277218 @default.
• W2409321621 cites W2108416075 @default.
• W2409321621 cites W2111567870 @default.
• W2409321621 cites W2112446953 @default.
• W2409321621 cites W2114138650 @default.
• W2409321621 cites W2119723870 @default.
• W2409321621 cites W2120166249 @default.
• W2409321621 cites W2121484716 @default.
• W2409321621 cites W2124070987 @default.
• W2409321621 cites W2134729501 @default.
• W2409321621 cites W2138258120 @default.
• W2409321621 cites W2138328097 @default.
• W2409321621 cites W2153059487 @default.
• W2409321621 cites W2159920620 @default.
• W2409321621 cites W2175868873 @default.
• W2409321621 cites W2192080449 @default.
• W2409321621 cites W2321205867 @default.
• W2409321621 cites W2335397937 @default.
• W2409321621 cites W2398090914 @default.
• W2409321621 cites W4246700435 @default.
• W2409321621 cites W4292198229 @default.
• W2409321621 cites W637887512 @default.
• W2409321621 cites W2418617059 @default.
• W2409321621 doi "https://doi.org/10.3945/ajcn.115.123786" @default.
• W2409321621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4919525" @default.
• W2409321621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27281309" @default.
• W2409321621 hasPublicationYear "2016" @default.
• W2409321621 type Work @default.
• W2409321621 sameAs 2409321621 @default.
• W2409321621 citedByCount "69" @default.
• W2409321621 countsByYear W24093216212016 @default.
• W2409321621 countsByYear W24093216212017 @default.
• W2409321621 countsByYear W24093216212018 @default.
• W2409321621 countsByYear W24093216212019 @default.
• W2409321621 countsByYear W24093216212020 @default.
• W2409321621 countsByYear W24093216212021 @default.
• W2409321621 countsByYear W24093216212022 @default.
• W2409321621 countsByYear W24093216212023 @default.
• W2409321621 crossrefType "journal-article" @default.
• W2409321621 hasAuthorship W2409321621A5002536253 @default.
• W2409321621 hasAuthorship W2409321621A5005112247 @default.
• W2409321621 hasAuthorship W2409321621A5011739304 @default.
• W2409321621 hasAuthorship W2409321621A5023182644 @default.
• W2409321621 hasAuthorship W2409321621A5037139777 @default.
• W2409321621 hasAuthorship W2409321621A5041496187 @default.
• W2409321621 hasAuthorship W2409321621A5046643472 @default.

• next