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• W2409326517 abstract "The mitochondrial NAD(P)+ malic enzyme [EC 1.1.1.39, L-malate:NAD+ oxidoreductase (decarboxylating)] was purified from rabbit heart to a specific activity of 7 units (mumol/min)/mg at 23 degrees C. A study of the reductive carboxylation reaction indicates that this enzymic reaction is reversible. The rate of the reductive carboxylation reaction appears to be completely inhibited at an NADH concentration of 0.92 mM. A substrate saturation curve of this reaction with NADH as the varied substrate describes this inhibition. The apparent kinetic parameters for this reaction are Ka(NADH) = 239 microM and Vr = 1.1 mumol/min per mg at 23 degrees C. The steady-state product-inhibition patterns for pyruvate and NADH indicate a sequential binding of the substrates: NAD+ followed by L-malate. These data also indicate that NADH is the last product released. A steady-state kinetic model is proposed that incorporates NADH-enzyme dead-end complexes." @default.
• W2409326517 created "2016-06-24" @default.
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• W2409326517 date "1985-01-15" @default.
• W2409326517 modified "2023-09-25" @default.
• W2409326517 title "The purification and steady-state kinetic behaviour of rabbit heart mitochondrial NAD(P)+ malic enzyme" @default.
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• W2409326517 doi "https://doi.org/10.1042/bj2250335" @default.
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