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• W2409355035 endingPage "362" @default.
• W2409355035 startingPage "337" @default.
• W2409355035 abstract "There are many factors which are known to cause variability in human in vitro enzyme kinetic data. Factors such as the source of enzyme and how it was prepared, the genetics and background of the donor, how the in vitro studies are designed, and how the data are analyzed contribute to variability in the resulting kinetic parameters. It is important to consider not only the factors which cause variability within an experiment, such as selection of a probe substrate, but also those that cause variability when comparing kinetic data across studies and laboratories. For example, the artificial nature of the microsomal lipid membrane and microenvironment in some recombinantly expressed enzymes, relative to those found in native tissue microsomes, has been shown to influence enzyme activity and thus can be a source of variability when comparing across the two different systems. All of these factors, and several others, are discussed in detail in the chapter below." @default.
• W2409355035 created "2016-06-24" @default.
• W2409355035 creator A5073007668 @default.
• W2409355035 creator A5090779784 @default.
• W2409355035 date "2014-01-01" @default.
• W2409355035 modified "2023-09-27" @default.
• W2409355035 title "Variability in Human In Vitro Enzyme Kinetics" @default.
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• W2409355035 doi "https://doi.org/10.1007/978-1-62703-758-7_16" @default.
• W2409355035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34272704" @default.
• W2409355035 hasPublicationYear "2014" @default.
• W2409355035 type Work @default.

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