FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409356041> ?p ?o ?g. }

• W2409356041 endingPage "2321" @default.
• W2409356041 startingPage "2312" @default.
• W2409356041 abstract "1. The effect of kainate and other glutamatergic agonists on the membrane potential (Em), the intracellular Na+ activity (aNai), and the intracellular free Ca2+ concentration ([Ca2+]i) of identified leech neurons and neuropile glial cells was measured with conventional and ion-sensitive microelectrodes, as well as with the use of the iontophoretically injected fluorescent indicators sodium-binding benzofuran isophthalate and Fura-2. 2. In Retzius neurons, AE, L, 8, and 101 motoneurons, and in the unclassified 50 neurons (Leydig cells) and AP neurons, as well as in neuropile glial cells, bath application of 100 microM kainate evoked a marked membrane depolarization and an increase in aNai and [Ca2+]i. The kainate-induced aNai increase persisted in solutions with high Mg2+ concentration in which synaptic transmission is blocked. 3. A membrane depolarization as well as an increase in aNai and [Ca2+]i was also evoked by L-glutamate, quisqualate, and L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA). The agonist-induced [Ca2+]i increase was inhibited by 6,7-dinitroquinoxaline-2,3-dione (DNQX). 4. In Ca(2+)-free solution, the kainate-induced [Ca2+]i increase was abolished in the neurons and in neuropile glial cells, whereas membrane depolarization and aNai increase were unchanged. In Na(+)-free solution, kainate had no effect on Em, aNai, or [Ca2+]i in the neurons. 5. In the mechanosensory T, P, and N neurons, kainate induced considerably smaller membrane depolarizations than in the other neurons or in neuropile glial cells, and it had no significant effect on aNai or [Ca2+]i. 6. It is concluded that in leech segmental ganglia the majority of the neurons and the neuropile glial cells, but probably not the mechanosensory neurons, possess glutamate receptors of the AMPA-kainate type. In the neurons, the [Ca2+]i increase caused by glutamatergic agonists is due to Ca2+ influx through voltage-dependent Ca2+ channels that are activated by the agonist-induced membrane depolarization." @default.
• W2409356041 created "2016-06-24" @default.
• W2409356041 creator A5006147212 @default.
• W2409356041 creator A5051292728 @default.
• W2409356041 creator A5059202608 @default.
• W2409356041 date "1996-06-01" @default.
• W2409356041 modified "2023-09-24" @default.
• W2409356041 title "Distribution and functional properties of glutamate receptors in the leech central nervous system" @default.
• W2409356041 cites W1513072184 @default.
• W2409356041 cites W1595593492 @default.
• W2409356041 cites W1945461692 @default.
• W2409356041 cites W1976271922 @default.
• W2409356041 cites W1977445639 @default.
• W2409356041 cites W1986041854 @default.
• W2409356041 cites W1990031180 @default.
• W2409356041 cites W2001239401 @default.
• W2409356041 cites W2020232993 @default.
• W2409356041 cites W2027555840 @default.
• W2409356041 cites W2038554778 @default.
• W2409356041 cites W2041821121 @default.
• W2409356041 cites W2042414655 @default.
• W2409356041 cites W2047023568 @default.
• W2409356041 cites W2047132570 @default.
• W2409356041 cites W2056207465 @default.
• W2409356041 cites W2059939266 @default.
• W2409356041 cites W2065699773 @default.
• W2409356041 cites W2066439059 @default.
• W2409356041 cites W2069469985 @default.
• W2409356041 cites W2071956912 @default.
• W2409356041 cites W2075868946 @default.
• W2409356041 cites W2078688317 @default.
• W2409356041 cites W2080278914 @default.
• W2409356041 cites W2082088575 @default.
• W2409356041 cites W2082474912 @default.
• W2409356041 cites W2093734160 @default.
• W2409356041 cites W2104452142 @default.
• W2409356041 cites W2107650772 @default.
• W2409356041 cites W2111062311 @default.
• W2409356041 cites W2139002266 @default.
• W2409356041 cites W2141260882 @default.
• W2409356041 cites W2144348977 @default.
• W2409356041 cites W2162567850 @default.
• W2409356041 cites W2165834441 @default.
• W2409356041 cites W2278833334 @default.
• W2409356041 cites W2315829194 @default.
• W2409356041 cites W2324966829 @default.
• W2409356041 cites W3021109263 @default.
• W2409356041 cites W1980513985 @default.
• W2409356041 doi "https://doi.org/10.1152/jn.1996.75.6.2312" @default.
• W2409356041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8793744" @default.
• W2409356041 hasPublicationYear "1996" @default.
• W2409356041 type Work @default.
• W2409356041 sameAs 2409356041 @default.
• W2409356041 citedByCount "38" @default.
• W2409356041 countsByYear W24093560412014 @default.
• W2409356041 countsByYear W24093560412015 @default.
• W2409356041 countsByYear W24093560412020 @default.
• W2409356041 countsByYear W24093560412021 @default.
• W2409356041 crossrefType "journal-article" @default.
• W2409356041 hasAuthorship W2409356041A5006147212 @default.
• W2409356041 hasAuthorship W2409356041A5051292728 @default.
• W2409356041 hasAuthorship W2409356041A5059202608 @default.
• W2409356041 hasConcept C12554922 @default.
• W2409356041 hasConcept C160268369 @default.
• W2409356041 hasConcept C169760540 @default.
• W2409356041 hasConcept C170493617 @default.
• W2409356041 hasConcept C181911157 @default.
• W2409356041 hasConcept C185592680 @default.
• W2409356041 hasConcept C189184402 @default.
• W2409356041 hasConcept C200170125 @default.
• W2409356041 hasConcept C2776108384 @default.
• W2409356041 hasConcept C2777075645 @default.
• W2409356041 hasConcept C4141045 @default.
• W2409356041 hasConcept C55493867 @default.
• W2409356041 hasConcept C61174792 @default.
• W2409356041 hasConcept C86803240 @default.
• W2409356041 hasConcept C95444343 @default.
• W2409356041 hasConceptScore W2409356041C12554922 @default.
• W2409356041 hasConceptScore W2409356041C160268369 @default.
• W2409356041 hasConceptScore W2409356041C169760540 @default.
• W2409356041 hasConceptScore W2409356041C170493617 @default.
• W2409356041 hasConceptScore W2409356041C181911157 @default.
• W2409356041 hasConceptScore W2409356041C185592680 @default.
• W2409356041 hasConceptScore W2409356041C189184402 @default.
• W2409356041 hasConceptScore W2409356041C200170125 @default.
• W2409356041 hasConceptScore W2409356041C2776108384 @default.
• W2409356041 hasConceptScore W2409356041C2777075645 @default.
• W2409356041 hasConceptScore W2409356041C4141045 @default.
• W2409356041 hasConceptScore W2409356041C55493867 @default.
• W2409356041 hasConceptScore W2409356041C61174792 @default.
• W2409356041 hasConceptScore W2409356041C86803240 @default.
• W2409356041 hasConceptScore W2409356041C95444343 @default.
• W2409356041 hasIssue "6" @default.
• W2409356041 hasLocation W24093560411 @default.
• W2409356041 hasLocation W24093560412 @default.
• W2409356041 hasOpenAccess W2409356041 @default.
• W2409356041 hasPrimaryLocation W24093560411 @default.
• W2409356041 hasRelatedWork W1963965929 @default.

• next