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• W2409366924 endingPage "1069" @default.
• W2409366924 startingPage "1069" @default.
• W2409366924 abstract "The ability of zebrafish to faithfully recapitulate a variety of human cancers provides a unique in vivo system for drug identification and validation. Zebrafish models of human cancer generated through methodologies such as transgenesis, gene inactivation, transplantation, and carcinogenic induction have proven similar to their human counterparts both molecularly and pathologically. Suppression of cancer-relevant phenotypes provides opportunities to both identify and evaluate efficacious compounds using embryonic and adult zebrafish. After relevant compounds are selected, preclinical evaluation in mammalian models can occur, delivering lead compounds to human trials swiftly and rapidly. The advantages of in vivo imaging, large progeny, and rapid development that the zebrafish provides make it an attractive model to promote novel cancer drug discovery and reduce the hurdles and cost of clinical trials. This review explores the current methodologies to model human cancers in zebrafish, and how these cancer models have aided in formation of novel therapeutic hypotheses." @default.
• W2409366924 created "2016-06-24" @default.
• W2409366924 creator A5005126432 @default.
• W2409366924 creator A5049375844 @default.
• W2409366924 creator A5062210836 @default.
• W2409366924 date "2016-02-03" @default.
• W2409366924 modified "2023-10-02" @default.
• W2409366924 title "The Zebrafish as a Tool to Cancer Drug Discovery." @default.
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