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- W2409378672 abstract "12 patients with obstructive airway diseases were given a single oral dose of 400 mg resp. 600 mg Cholintheophyllinate (Euspirax) and 350 mg Theophyllin-Aethylendiamine (Euphyllin retard). In an intra-individual comparative study the theophylline-serum-concentrations and the bronchospasmolytic effects of both drugs have been checked over a period of 12 hours. A very good resorption and the highest mean blood levels of 9,13 +/- 2,88 mg/1 resp. 12,11 +/- 2,55 mg/1 resulted from Cholintheophyllinate 2 hours after application. The effect on the lung function parameters was most expressed 2 to 4 hours after application of this drug and correlated well with the theophylline-blood-levels. The higher dose of Euspirax was followed more frequently by side effects. 2, 4 and 12 hours after application of Euphyllin retard the serum-concentrations were strikingly low. The mean values were 2,04 +/- 1,22 mg/l, 3,00 +/- 2,18 mg/l resp. 3,38 +/- 2,01 mg/l. In spite of the low blood levels a significant improvement of the lung function parameters could be noticed after 4 to 6 hours. The qualities of both drugs as to their bioavailability and effect on airway obstruction shall be examined by means of another comparative study." @default.
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- W2409378672 date "1979-11-01" @default.
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- W2409378672 title "[Comparative examination of theophylline-serum-concentrations and bronchospasmolytic effect of cholintheophyllinate (euspirax) and theophyllin-aethylendiamine (euphyllin retard) in patients with obstructive airway diseases (author's transl)]." @default.
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