Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409390147> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2409390147 endingPage "55" @default.
- W2409390147 startingPage "349" @default.
- W2409390147 abstract "Thirty-one healthy young pigs were studied to evaluate the effects of methylprednisolone sodium succinate (MP) on cellular, proteolytic, and hemodynamic parameters in normal and endotoxin-exposed animals. Fourteen animals served as controls, whereas 17 test animals received a continuous infusion of endotoxin, 0.01 mg/kg/3hr. Seven of the test animals and seven of the control group received a total of 200 mg/kg body weight over 5 hr of MP, 100 mg/kg as pretreatment before the endotoxin infusion was started. The administration of MP to control animals did not cause changes in the plasma kallikrein-kinin system, as determined with chromogenic peptide substrate assays. Only temporary effects, which normalized during the observation period, were seen in hemodynamic parameters. The pretreatment with MP significantly counteracted the increases in plasma kallikrein activity (KK) and the decreases in functional kallikrein inhibition capacity (KKI) seen after endotoxin infusion in untreated animals. Marked reductions in the number of circulating leukocytes and platelets were observed in untreated endotoxemia, together with increases in hematocrit. Furthermore, increases in pulmonary vascular resistance (PVR) and decreases in cardiac output (CO), left ventricular stroke work (LVSW), and mixed venous oxygen saturation (SvO2) ensued. The changes in circulating cells, PVR, and SvO2 were significantly counteracted by MP treatment, whereas changes in hematocrit, CO, and LVSW were only moderately improved." @default.
- W2409390147 created "2016-06-24" @default.
- W2409390147 creator A5022916691 @default.
- W2409390147 creator A5030917387 @default.
- W2409390147 creator A5052477622 @default.
- W2409390147 creator A5061544930 @default.
- W2409390147 creator A5082745725 @default.
- W2409390147 creator A5089753464 @default.
- W2409390147 date "1991-08-01" @default.
- W2409390147 modified "2023-09-27" @default.
- W2409390147 title "Plasma kallikrein generation in endotoxemia is abolished by ultra high doses of methyl-prednisolone: in vivo studies in a pig model." @default.
- W2409390147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1773478" @default.
- W2409390147 hasPublicationYear "1991" @default.
- W2409390147 type Work @default.
- W2409390147 sameAs 2409390147 @default.
- W2409390147 citedByCount "1" @default.
- W2409390147 crossrefType "journal-article" @default.
- W2409390147 hasAuthorship W2409390147A5022916691 @default.
- W2409390147 hasAuthorship W2409390147A5030917387 @default.
- W2409390147 hasAuthorship W2409390147A5052477622 @default.
- W2409390147 hasAuthorship W2409390147A5061544930 @default.
- W2409390147 hasAuthorship W2409390147A5082745725 @default.
- W2409390147 hasAuthorship W2409390147A5089753464 @default.
- W2409390147 hasConcept C126322002 @default.
- W2409390147 hasConcept C134018914 @default.
- W2409390147 hasConcept C139940330 @default.
- W2409390147 hasConcept C150903083 @default.
- W2409390147 hasConcept C178853913 @default.
- W2409390147 hasConcept C181199279 @default.
- W2409390147 hasConcept C207001950 @default.
- W2409390147 hasConcept C2777649898 @default.
- W2409390147 hasConcept C2780959883 @default.
- W2409390147 hasConcept C52853521 @default.
- W2409390147 hasConcept C55493867 @default.
- W2409390147 hasConcept C58245268 @default.
- W2409390147 hasConcept C71924100 @default.
- W2409390147 hasConcept C86803240 @default.
- W2409390147 hasConceptScore W2409390147C126322002 @default.
- W2409390147 hasConceptScore W2409390147C134018914 @default.
- W2409390147 hasConceptScore W2409390147C139940330 @default.
- W2409390147 hasConceptScore W2409390147C150903083 @default.
- W2409390147 hasConceptScore W2409390147C178853913 @default.
- W2409390147 hasConceptScore W2409390147C181199279 @default.
- W2409390147 hasConceptScore W2409390147C207001950 @default.
- W2409390147 hasConceptScore W2409390147C2777649898 @default.
- W2409390147 hasConceptScore W2409390147C2780959883 @default.
- W2409390147 hasConceptScore W2409390147C52853521 @default.
- W2409390147 hasConceptScore W2409390147C55493867 @default.
- W2409390147 hasConceptScore W2409390147C58245268 @default.
- W2409390147 hasConceptScore W2409390147C71924100 @default.
- W2409390147 hasConceptScore W2409390147C86803240 @default.
- W2409390147 hasIssue "4" @default.
- W2409390147 hasLocation W24093901471 @default.
- W2409390147 hasOpenAccess W2409390147 @default.
- W2409390147 hasPrimaryLocation W24093901471 @default.
- W2409390147 hasRelatedWork W165974812 @default.
- W2409390147 hasRelatedWork W1964054637 @default.
- W2409390147 hasRelatedWork W1965614408 @default.
- W2409390147 hasRelatedWork W1981010395 @default.
- W2409390147 hasRelatedWork W2001993577 @default.
- W2409390147 hasRelatedWork W2016165741 @default.
- W2409390147 hasRelatedWork W2082640992 @default.
- W2409390147 hasRelatedWork W2262960006 @default.
- W2409390147 hasRelatedWork W3149745373 @default.
- W2409390147 hasRelatedWork W2740486531 @default.
- W2409390147 hasVolume "34" @default.
- W2409390147 isParatext "false" @default.
- W2409390147 isRetracted "false" @default.
- W2409390147 magId "2409390147" @default.
- W2409390147 workType "article" @default.